Details of Metabolite

General Information of MET (ID: META00990)
Name AT-Resolvin D1
Synonyms   Click to Show/Hide Synonyms of This Metabolite
AT-Resolvin D1; AT-RvD1; aspirin-triggered resolvin D1; (4Z,7S,8R,9E,11E,13Z,15E,17R,19Z)-7,8,17-trihydroxydocosa-4,9,11,13,15,19-hexaenoic acid; 17(R)-Resolvin D1; 7S,8R,17R-trihydroxy-4Z,9E,11E,13Z,15E,19Z-docosahexaenoic acid; 528583-91-7; 17-epi-resolvin D1; CHEMBL519495; GTPL6239; SCHEMBL12698977; CHEBI:138179; 1499AH; LMFA04030005; ZINC35328245; Q27074550; 7S,8R,17R-Trihydroxy-4Z,9E,11E,13Z,15E19Z-docosahexaenoic acid; (4Z,7S,8R,9E,11E,13Z,15E,17R,19Z)-7,8,17-trihydroxydocosahexaenoic acid
Source Endogenous;Food
Structure Type   Fatty acids and conjugates  (Click to Show/Hide the Complete Structure Type Hierarchy)
Lipids and lipid-like molecules
Fatty Acyls
Fatty acids and conjugates
PubChem CID
16126783
Formula
C22H32O5
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=16126783"></iframe>
3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
Physicochemical Properties Molecular Weight 376.5 Topological Polar Surface Area 98
XlogP 3.1 Complexity 555
Heavy Atom Count 27 Rotatable Bond Count 14
Hydrogen Bond Donor Count 4 Hydrogen Bond Acceptor Count 5
Regulatory Network
Full List of Protein(s) Regulated by This Metabolite
      GPCR rhodopsin (GPCR-1)
            FMLP-related receptor I (FPR2) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation AT-Resolvin D1 addition (1 hours)
                      Induced Change FPR2 protein activity levels: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Peritonitis [ICD-11: DC50]
                      Details It is reported that AT-resolvin D1 addition causes the increase of FPR2 protein activity compared with control group.
            G-protein coupled receptor 32 (GPR32) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation AT-Resolvin D1 addition (1 hours)
                      Induced Change GPR32 protein activity levels: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Peritonitis [ICD-11: DC50]
                      Details It is reported that AT-resolvin D1 addition causes the increase of GPR32 protein activity compared with control group.
References
1 Resolvin D1 receptor stereoselectivity and regulation of inflammation and proresolving microRNAs. Am J Pathol. 2012 May;180(5):2018-27.

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