Details of Metabolite

General Information of MET (ID: META00951)
Name 5-Dodecenoylcarnitine
Source Aliphatic acyclic compounds
Structure Type   Fatty acid esters  (Click to Show/Hide the Complete Structure Type Hierarchy)
Lipids and lipid-like molecules
Fatty Acyls
Fatty acid esters
PubChem CID
139947491
HMDB ID
HMDB0241212
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=139947491"></iframe>
3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
Physicochemical Properties Molecular Weight 341.5 Topological Polar Surface Area 66.4
XlogP 4.6 Complexity 380
Heavy Atom Count 24 Rotatable Bond Count 14
Hydrogen Bond Donor Count N.A. Hydrogen Bond Acceptor Count 4
Function
5-Dodecenoylcarnitine is an acylcarnitine. It is an dodec-5-enoic acid ester of carnitine.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Oxidoreductases (EC 1)
            Formyltetrahydrofolate dehydrogenase (ALDH1L2) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Mutation of ALDH1L2
                      Induced Change 5-Dodecenoylcarnitine concentration: increase (FC = 2.94)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Genetic disorders of keratinisation [ICD-11: EC20]
                      Details It is reported that mutation (patients) of ALDH1L2 leads to the increase of 5-dodecenoylcarnitine levels compared with control group.
References
1 Deleterious mutations in ALDH1L2 suggest a novel cause for neuro-ichthyotic syndrome. NPJ Genom Med. 2019 Jul 23;4:17.

If you find any error in data or bug in web service, please kindly report it to Dr. Zhang and Dr. Mou.