Details of Metabolite

General Information of MET (ID: META00948)
Name Docosapentaenoylcarnitine
Synonyms   Click to Show/Hide Synonyms of This Metabolite
(7Z,10Z,13Z,16Z,19Z)-docosapentaenoylcarnitine; all-cis-7,10,13,16,19-docosapentaenoylcarnitine; O-[(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl]carnitine; 3-[(7Z,10Z,13Z,16Z,19Z)-docosa-7,10,13,16,19-pentaenoyloxy]-4-(trimethylammonio)butanoate; 3-[(7Z,10Z,13Z,16Z,19Z)-docosa-7,10,13,16,19-pentaenoyloxy]-4-(trimethylazaniumyl)butanoate
Structure Type   Fatty acid esters  (Click to Show/Hide the Complete Structure Type Hierarchy)
Lipids and lipid-like molecules
Fatty Acyls
Fatty acid esters
PubChem CID
71464594
HMDB ID
HMDB0240759
Formula
C29H47NO4
Structure
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3D MOL is unavailable 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
Physicochemical Properties Molecular Weight 473.7 Topological Polar Surface Area 66.4
XlogP 7.3 Complexity 675
Heavy Atom Count 34 Rotatable Bond Count 20
Hydrogen Bond Donor Count N.A. Hydrogen Bond Acceptor Count 4
Function
(7Z,10Z,13Z,16Z,19Z)-Docosapentaenoylcarnitine is an acylcarnitine. The general role of acylcarnitines is to transport acyl-groups (organic acids and fatty acids) from the cytoplasm into the mitochondria so that they can be broken down to produce energy.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Oxidoreductases (EC 1)
            Formyltetrahydrofolate dehydrogenase (ALDH1L2) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Mutation of ALDH1L2
                      Induced Change Docosapentaenoylcarnitine concentration: increase (FC = 1.56)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Genetic disorders of keratinisation [ICD-11: EC20]
                      Details It is reported that mutation (patients) of ALDH1L2 leads to the increase of docosapentaenoylcarnitine levels compared with control group.
References
1 Deleterious mutations in ALDH1L2 suggest a novel cause for neuro-ichthyotic syndrome. NPJ Genom Med. 2019 Jul 23;4:17.

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