Details of Metabolite

General Information of MET (ID: META00940)
Name Cyclohexylammonium
Synonyms   Click to Show/Hide Synonyms of This Metabolite
CYCLOHEXYLAMMONIUM ion; Cyclohexylamine
Source Drug
Structure Type   Cyclohexylamines  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic nitrogen compounds
Organonitrogen compounds
Cyclohexylamines
PubChem CID
1549093
HMDB ID
HMDB0062716
Formula
C6H14N
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
DrugBank ID
DB02995
ChEBI ID
42939
Physicochemical Properties Molecular Weight 100.18 Topological Polar Surface Area 27.6
XlogP 1.5 Complexity 46.1
Heavy Atom Count 7 Rotatable Bond Count N.A.
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count N.A.
Function
Cyclohexylammonium is classified as a member of the Cyclohexylamines. Cyclohexylamines are organic compounds containing a cyclohexylamine moiety, which consist of a cyclohexane ring attached to an amine group. Cyclohexylammonium is considered to be practically insoluble (in water) and basic
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Pore-forming PNC peptide (PNC)
            Cellular tumor antigen p53 (TP53) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout of TP53
                      Induced Change Cyclohexylammonium concentration: decrease (Log2 FC=0.71)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Colon cancer [ICD-11: 2B90]
                      Details It is reported that knockout of TP53 leads to the decrease of cyclohexylammonium levels compared with control group.
References
1 Integrative omics analysis of p53-dependent regulation of metabolism. FEBS Lett. 2018 Feb;592(3):380-393.

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