Details of Metabolite

General Information of MET (ID: META00916)
Name Triethanolamine
Synonyms   Click to Show/Hide Synonyms of This Metabolite
2,2',2''-NITRILOTRIETHANOL, 2,2',2''-Nitrilotris(ethanol), 'H3Tea; 637-39-8 (Unspecified hydrochloride); 7376-31-0 (Unspecified sulfate salt); 7376-31-0 (Unspecified sulphate salt); Alkano; Alkanolamine 244; BTB; Cerumenex; Daltogen', Ethanol, 2,2',2''-nitrilotris-, homopolymer, 'Mobisyl', Nitrilo-2,2',2quot -triethanol, 'Nitrilotris(ethanol); Mobisy; N(CH2CH2OH)3', Nitrilo-2,2',2''-triethanol, 'Nitrilotriethanol; Poly(triethanolamine) ether; Sodium isa; Sterolamide; Sting-kill; TEA; TEOA; Tea (amino alcohol); Thiofaco T-35; Tri(hydroxyethyl)amine; Triaethanolamin-NG; Triethanolamin; Triethanolamin-NG; Triethanolamine acetate; Triethanolamine citrate; Triethanolamine citrate (1:1); Triethanolamine condensate polymer; Triethanolamine copper salt; Triethanolamine homopolymer; Triethanolamine hydrochloride; Triethanolamine iodohydrate; Triethanolamine maleate; Triethanolamine phosphate; Triethanolamine sulfate; Triethanolamine sulfate (2:1); Triethanolamine sulfite (1:1); Triethanolamine tartrate (1:1), (R-(r*,r*))-isomer; Triethanolamine titanium salt; Triethanolammonium chloride; Triethylolamine; Trihydroxyethylamine; Trihydroxytriethylamine; Tris(2-hydroxyethyl) amine; Tris(2-hydroxyethyl)amine; Tris(beta -hydroxyethyl)amine; Tris(beta-hydroxyethyl)amine; Tris(hydroxyethyl)amine; Trola; Trolamine; Trolamine (NF)
Source Aliphatic acyclic compounds
Structure Type   Amines  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic nitrogen compounds
Organonitrogen compounds
Amines
PubChem CID
7618
HMDB ID
HMDB0032538
Formula
C6H15NO3
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C06771
DrugBank ID
DB13747
ChEBI ID
28621
FooDB ID
FDB010410
ChemSpider ID
13835630
Physicochemical Properties Molecular Weight 149.19 Topological Polar Surface Area 63.9
XlogP -1 Complexity 55.7
Heavy Atom Count 10 Rotatable Bond Count 6
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 4
Function
Triethanolamine is used as a food additive [EAFUS] ("EAFUS: Everything Added to Food in the United States. [http://www.eafus.com/]")
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Pore-forming PNC peptide (PNC)
            Cellular tumor antigen p53 (TP53) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout of TP53
                      Induced Change Triethanolamine concentration: decrease (Log2 FC=0.75)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Colon cancer [ICD-11: 2B90]
                      Details It is reported that knockout of TP53 leads to the decrease of triethanolamine levels compared with control group.
References
1 Integrative omics analysis of p53-dependent regulation of metabolism. FEBS Lett. 2018 Feb;592(3):380-393.

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