General Information of MET (ID: META00906)
Name Glutaral
Synonyms   Click to Show/Hide Synonyms of This Metabolite
1,3-Diformyl propane; 1,3-Diformylpropane; 1,5-Pentanedial; 1,5-Pentanedione; Aldehyd glutarowy; Aldesan; Aldesen; Alhydex; Aqucar; Bactron K31; Bioglan brand OF glutaral; Bode brand OF glutaral; Cahill may roberts brand OF glutaral; Cidex; Cidex 7; Coldcide-25 microbiocide; Dermal brand OF glutaral; Dermatech brand OF glutaral; Dioxopentane; Diswart; Ecolab brand OF glutaral; GLUTARALDEHYDE, 25% soln; Gludesin; Glutaclean; Glutaral; Glutaral(usan); Glutaral, inn, usan; Glutaraldehyd; Glutaraldehyde; Glutaralum; Glutarate dialdehyde; Glutardialdehyde; Glutarex 28; Glutaric acid dialdehyde; Glutaric aldehyde; Glutaric dialdehyde; Glutarol; Glutarol-1,5-pentanedial; Gluteraldehyde; Glutural; Hospex; Johnson and johnson brand OF glutaral; Korsolex; Novaruca; PENTANEDIAL; PTD; Pentane-1,5-dial; Pentanedial, homopolymer; Poly(glutaraldehyde); Polyglutaraldehyde; Potentiated acid glutaraldehyde; Protectol gda, GT 50; Relugan GT; Relugan GT 50; Relugan GTW; Sekumatic; Sonacide; Sporicidin; Sterihyde; Sterihyde L; Ucarcide; Ucarcide 225; Ucarcide 250; Ucarset; Veruca-sep; Verucasep; Virsal
Source Endogenous;Food;Carcinogenic Potency;Drug;Agricultural Chemicals;Toxins/Pollutant;Cosmetic;Food additives
Structure Type   Carbonyl compounds  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic oxygen compounds
Organooxygen compounds
Carbonyl compounds
PubChem CID
3485
HMDB ID
HMDB0029599
Formula
C5H8O2
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C12518
DrugBank ID
DB03266
ChEBI ID
64276
FooDB ID
FDB000763
ChemSpider ID
3365
Physicochemical Properties Molecular Weight 100.12 Topological Polar Surface Area 34.1
XlogP -0.5 Complexity 51.1
Heavy Atom Count 7 Rotatable Bond Count 4
Hydrogen Bond Donor Count N.A. Hydrogen Bond Acceptor Count 2
Function
Glutaral is used as an antimicrobial agent in sugar mills and as a fixing agent in the immobilisation of glucose isomerase enzyme preparations for use in the manufacture of high fructose corn syrup A polymerized isomer of glutaraldehyde known as polycycloglutaracetal is a fertilizer for aquatic plants. It is claimed that it provides a bioavailable source of carbon for higher plants that is not available to algae. Though not marketed as such due to federal regulations, the biocidal effect of glutaraldehyde kills most algae at concentrations of 0.5 - 5.0 ppm. These levels are not harmful to most aquatic fauna and flora. Adverse reactions have been observed by some aquarists at these concentrations in some aquatic mosses, liverworts, and vascular plants. Glutaraldehyde is a colorless liquid with a pungent odor used to disinfect medical and dental equipment. It is also used for industrial water treatment and as a chemical preservative. Glutaraldehyde is an oily liquid at room temperature (density 1.06 g/mL), and miscible with water, alcohol, and benzene. It is used as a tissue fixative in electron microscopy. It is employed as an embalming fluid, is a component of leather tanning solutions, and occurs as an intermediate in the production of certain industrial chemicals. Glutaraldehyde is frequently used in biochemistry applications as an amine-reactive homobifunctional crosslinker. The oligomeric state of proteins can be examined through this application. However, it is toxic, causing severe eye, nose, throat and lung irritation, along with headaches, drowsiness and dizziness. It is a main source of occupational asthma among health care providers
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Pore-forming PNC peptide (PNC)
            Cellular tumor antigen p53 (TP53) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout of TP53
                      Induced Change Glutaral concentration: decrease (Log2 FC=0.77)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Colon cancer [ICD-11: 2B90]
                      Details It is reported that knockout of TP53 leads to the decrease of glutaral levels compared with control group.
References
1 Integrative omics analysis of p53-dependent regulation of metabolism. FEBS Lett. 2018 Feb;592(3):380-393.

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