Details of Metabolite

General Information of MET (ID: META00902)
Name Threonylaspartic acid
Synonyms   Click to Show/Hide Synonyms of This Metabolite
L-THR-L-Asp; L-Threoninyl-L-aspartate; L-Threoninyl-L-aspartic acid; L-Threonyl-L-aspartate; L-Threonyl-L-aspartic acid; N-L-Threoninyl-L-aspartate; N-L-Threoninyl-L-aspartic acid; N-L-Threonyl-L-aspartate; N-L-Threonyl-L-aspartic acid; N-Threoninylaspartate; N-Threoninylaspartic acid; N-Threonylaspartate; N-Threonylaspartic acid; T-D dipeptide; TD; TD dipeptide; Thr-Asp; Threonine aspartate dipeptide; Threonine aspartic acid dipeptide; Threonine-aspartate dipeptide; Threonine-aspartic acid dipeptide; Threoninyl-aspartate; Threoninyl-aspartic acid; Threoninylaspartate; Threoninylaspartic acid; Threonyl-aspartate; Threonyl-aspartic acid; Threonylaspartate; Threonylaspartic acid
Source Endogenous;Endogenous
Structure Type   Amino acids, peptides, and analogues  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic acids and derivatives
Carboxylic acids and derivatives
Amino acids, peptides, and analogues
PubChem CID
7016067
HMDB ID
HMDB0029057
Formula
C8H14N2O6
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
ChEBI ID
74854
ChemSpider ID
5379089
Physicochemical Properties Molecular Weight 234.21 Topological Polar Surface Area 150
XlogP -4.7 Complexity 292
Heavy Atom Count 16 Rotatable Bond Count 6
Hydrogen Bond Donor Count 5 Hydrogen Bond Acceptor Count 7
Function
Threonylaspartic acid is a dipeptide composed of threonine and aspartic acid. It is an incomplete breakdown product of protein digestion or protein catabolism. Dipeptides are organic compounds containing a sequence of exactly two alpha-amino acids joined by a peptide bond. Some dipeptides are known to have physiological or cell-signalling effects although most are simply short-lived intermediates on their way to specific amino acid degradation pathways following further proteolysis.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Pore-forming PNC peptide (PNC)
            Cellular tumor antigen p53 (TP53) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout of TP53
                      Induced Change Threonylaspartic acid concentration: decrease (Log2 FC=0.82)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Colon cancer [ICD-11: 2B90]
                      Details It is reported that knockout of TP53 leads to the decrease of threonylaspartic acid levels compared with control group.
References
1 Integrative omics analysis of p53-dependent regulation of metabolism. FEBS Lett. 2018 Feb;592(3):380-393.

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