General Information of MET (ID: META00899)
Name Prolyl-Methionine
Synonyms   Click to Show/Hide Synonyms of This Metabolite
2-{[hydroxy(pyrrolidin-2-yl)methylidene]amino}-4-(methylsulfanyl)butanoate; 2-{[hydroxy(pyrrolidin-2-yl)methylidene]amino}-4-(methylsulphanyl)butanoate; 2-{[hydroxy(pyrrolidin-2-yl)methylidene]amino}-4-(methylsulphanyl)butanoic acid; L-Prolyl-L-methionine; PM Dipeptide; Pro-met; Proline methionine dipeptide; Proline-methionine dipeptide; Prolylmethionine; p-m Dipeptide
Source Endogenous;Endogenous
Structure Type   Amino acids, peptides, and analogues  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic acids and derivatives
Carboxylic acids and derivatives
Amino acids, peptides, and analogues
PubChem CID
5233577
HMDB ID
HMDB0029023
Formula
C10H18N2O3S
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
Physicochemical Properties Molecular Weight 246.33 Topological Polar Surface Area 104
XlogP -3.1 Complexity 260
Heavy Atom Count 16 Rotatable Bond Count 6
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 5
Function
Prolyl-Methionine is a dipeptide composed of proline and methionine. It is an incomplete breakdown product of protein digestion or protein catabolism. Some dipeptides are known to have physiological or cell-signaling effects although most are simply short-lived intermediates on their way to specific amino acid degradation pathways following further proteolysis. This dipeptide has not yet been identified in human tissues or biofluids and so it is classified as an 'Expected' metabolite.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Pore-forming PNC peptide (PNC)
            Cellular tumor antigen p53 (TP53) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout of TP53
                      Induced Change Prolyl-Methionine concentration: decrease (Log2 FC=0.75)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Colon cancer [ICD-11: 2B90]
                      Details It is reported that knockout of TP53 leads to the decrease of prolyl-methionine levels compared with control group.
References
1 Integrative omics analysis of p53-dependent regulation of metabolism. FEBS Lett. 2018 Feb;592(3):380-393.

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