General Information of MET (ID: META00894)
Name Phenylalanylthreonine
Synonyms   Click to Show/Hide Synonyms of This Metabolite
F-T; F-T Dipeptide; FT; FT Dipeptide; L-Phe-L-THR; L-Phenylalanyl-L-threonine; N-L-Phenylalanyl-L-threonine; N-Phenylalanylthreonine; Phe-THR; Phenylalanine threonine dipeptide; Phenylalanine-threonine dipeptide; Phenylalanyl-threonine; Phenylalanylthreonine
Source Aromatic homomonocyclic compounds
Structure Type   Amino acids, peptides, and analogues  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic acids and derivatives
Carboxylic acids and derivatives
Amino acids, peptides, and analogues
PubChem CID
18218233
HMDB ID
HMDB0029005
Formula
C13H18N2O4
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
ChEBI ID
73636
ChemSpider ID
8621027
Physicochemical Properties Molecular Weight 266.29 Topological Polar Surface Area 113
XlogP -3 Complexity 316
Heavy Atom Count 19 Rotatable Bond Count 6
Hydrogen Bond Donor Count 4 Hydrogen Bond Acceptor Count 5
Function
Phenylalanylthreonine is a dipeptide composed of phenylalanine and threonine. It is an incomplete breakdown product of protein digestion or protein catabolism. Dipeptides are organic compounds containing a sequence of exactly two alpha-amino acids joined by a peptide bond. Some dipeptides are known to have physiological or cell-signalling effects although most are simply short-lived intermediates on their way to specific amino acid degradation pathways following further proteolysis.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Pore-forming PNC peptide (PNC)
            Cellular tumor antigen p53 (TP53) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout of TP53
                      Induced Change Phenylalanylthreonine concentration: increase (Log2 FC=7.37)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Colon cancer [ICD-11: 2B90]
                      Details It is reported that knockout of TP53 leads to the increase of phenylalanylthreonine levels compared with control group.
References
1 Integrative omics analysis of p53-dependent regulation of metabolism. FEBS Lett. 2018 Feb;592(3):380-393.

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