Details of Metabolite

General Information of MET (ID: META00893)
Name Phenylalanylglutamic acid
Synonyms   Click to Show/Hide Synonyms of This Metabolite
F-E dipeptide; FE; FE dipeptide; L-Phe-L-glu; L-Phenylalanyl-L-glutamate; L-Phenylalanyl-L-glutamic acid; N-(3-Phenyl-L-alanyl)-L-glutamic acid; N-(3-Phenyl-L-alanyl)glutamic acid; N-(3-Phenylalanyl)glutamic acid; N-L-Phenylalanyl-L-glutamate; N-L-Phenylalanyl-L-glutamic acid; N-Phenylalanylglutamate; N-Phenylalanylglutamic acid; Phe-Glu; Phenylalanine glutamate dipeptide; Phenylalanine glutamic acid dipeptide; Phenylalanine-glutamate dipeptide; Phenylalanine-glutamic acid dipeptide; Phenylalanyl-glutamate; Phenylalanyl-glutamic acid; Phenylalanylglutamate; Phenylalanylglutamic acid
Source Aromatic homomonocyclic compounds
Structure Type   Amino acids, peptides, and analogues  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic acids and derivatives
Carboxylic acids and derivatives
Amino acids, peptides, and analogues
PubChem CID
151134
HMDB ID
HMDB0028994
Formula
C14H18N2O5
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
ChEBI ID
74712
ChemSpider ID
133206
Physicochemical Properties Molecular Weight 294.3 Topological Polar Surface Area 130
XlogP -3 Complexity 380
Heavy Atom Count 21 Rotatable Bond Count 8
Hydrogen Bond Donor Count 4 Hydrogen Bond Acceptor Count 6
Function
Phenylalanylglutamic acid is a dipeptide composed of phenylalanine and glutamic acid. It is an incomplete breakdown product of protein digestion or protein catabolism. Dipeptides are organic compounds containing a sequence of exactly two alpha-amino acids joined by a peptide bond. Some dipeptides are known to have physiological or cell-signalling effects although most are simply short-lived intermediates on their way to specific amino acid degradation pathways following further proteolysis.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Pore-forming PNC peptide (PNC)
            Cellular tumor antigen p53 (TP53) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout of TP53
                      Induced Change Phenylalanylglutamic acid concentration: increase (Log2 FC=1.44)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Colon cancer [ICD-11: 2B90]
                      Details It is reported that knockout of TP53 leads to the increase of phenylalanylglutamic acid levels compared with control group.
References
1 Integrative omics analysis of p53-dependent regulation of metabolism. FEBS Lett. 2018 Feb;592(3):380-393.

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