Details of Metabolite

General Information of MET (ID: META00890)
Name Lysylphenylalanine
Synonyms   Click to Show/Hide Synonyms of This Metabolite
K-F; K-F dipeptide; KF; KF dipeptide; L-Lys-L-phe; L-Lysyl-L-phenylalanine; Lys-Phe; Lysine phenylalanine dipeptide; Lysine-phenylalanine dipeptide; Lysyl-phenylalanine; Lysylphenylalanine; Lysylphenylalanine diacetate, (L)-isomer; Lysylphenylalanine dihydrochloride, (L)-isomer; Lysylphenylalanine monohydrochloride, (L)-isomer; N-L-Lysyl-3-phenyl-L-alanine; N-L-Lysyl-L-phenylalanine; N-Lysyl-3-phenylalanine; N-Lysylphenylalanine
Source Aromatic homomonocyclic compounds
Structure Type   Amino acids, peptides, and analogues  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic acids and derivatives
Carboxylic acids and derivatives
Amino acids, peptides, and analogues
PubChem CID
151410
HMDB ID
HMDB0028958
Formula
C15H23N3O3
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
ChEBI ID
73605
ChemSpider ID
133442
Physicochemical Properties Molecular Weight 293.36 Topological Polar Surface Area 118
XlogP -2.7 Complexity 330
Heavy Atom Count 21 Rotatable Bond Count 9
Hydrogen Bond Donor Count 4 Hydrogen Bond Acceptor Count 5
Function
Lysylphenylalanine is a dipeptide composed of lysine and phenylalanine. It is an incomplete breakdown product of protein digestion or protein catabolism. Dipeptides are organic compounds containing a sequence of exactly two alpha-amino acids joined by a peptide bond. Some dipeptides are known to have physiological or cell-signalling effects although most are simply short-lived intermediates on their way to specific amino acid degradation pathways following further proteolysis.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Pore-forming PNC peptide (PNC)
            Cellular tumor antigen p53 (TP53) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout of TP53
                      Induced Change Lysylphenylalanine concentration: increase (Log2 FC=1.01)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Colon cancer [ICD-11: 2B90]
                      Details It is reported that knockout of TP53 leads to the increase of lysylphenylalanine levels compared with control group.
References
1 Integrative omics analysis of p53-dependent regulation of metabolism. FEBS Lett. 2018 Feb;592(3):380-393.

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