General Information of MET (ID: META00889)
Name Lysylleucine
Synonyms   Click to Show/Hide Synonyms of This Metabolite
K-L dipeptide; KL; KL dipeptide; L-Lys-L-leu; L-Lys-leu; L-Lysyl-L-leucine; L-Lysyl-leucine; Lys-Leu; Lysine leucine dipeptide; Lysine-leucine dipeptide; Lysyl-leucine; Lysylisoleucine; Lysylleucine; N-L-Lysyl-L-leucine; N-Lysylleucine
Source Aliphatic acyclic compounds
Structure Type   Amino acids, peptides, and analogues  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic acids and derivatives
Carboxylic acids and derivatives
Amino acids, peptides, and analogues
PubChem CID
7016103
HMDB ID
HMDB0028955
Formula
C12H25N3O3
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
ChEBI ID
74561
ChemSpider ID
5379125
Physicochemical Properties Molecular Weight 259.35 Topological Polar Surface Area 118
XlogP -3 Complexity 269
Heavy Atom Count 18 Rotatable Bond Count 9
Hydrogen Bond Donor Count 4 Hydrogen Bond Acceptor Count 5
Function
Lysylleucine is a dipeptide composed of lysine and leucine. It is an incomplete breakdown product of protein digestion or protein catabolism. Dipeptides are organic compounds containing a sequence of exactly two alpha-amino acids joined by a peptide bond. Some dipeptides are known to have physiological or cell-signalling effects although most are simply short-lived intermediates on their way to specific amino acid degradation pathways following further proteolysis.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Pore-forming PNC peptide (PNC)
            Cellular tumor antigen p53 (TP53) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout of TP53
                      Induced Change Lysylleucine concentration: decrease (Log2 FC=0.89)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Colon cancer [ICD-11: 2B90]
                      Details It is reported that knockout of TP53 leads to the decrease of lysylleucine levels compared with control group.
References
1 Integrative omics analysis of p53-dependent regulation of metabolism. FEBS Lett. 2018 Feb;592(3):380-393.

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