Details of Metabolite

General Information of MET (ID: META00884)
Name Histidylisoleucine
Synonyms   Click to Show/Hide Synonyms of This Metabolite
(2S,3S)-2-{[(2S)-2-amino-3-(1H-imidazol-4-yl)propanoyl]amino}-3-methylpentanoate; (2S,3S)-2-{[(2S)-2-amino-3-(1H-imidazol-4-yl)propanoyl]amino}-3-methylpentanoic acid; H-I; H-I dipeptide; HI; HI dipeptide; His-Ile; Histidine isoleucine dipeptide; Histidine-isoleucine dipeptide; Histidinyl-isoleucine; Histidinylisoleucine; Histidyl-isoleucine; Histidylisoleucine; L-His-L-Ile; L-Histidinyl-L-isoleucine; L-Histidyl-L-isoleucine; N-Histidinylisoleucine; N-Histidylisoleucine; N-L-Histidinyl-L-isoleucine; N-L-Histidyl-L-isoleucine
Source Endogenous;Endogenous
Structure Type   Amino acids, peptides, and analogues  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic acids and derivatives
Carboxylic acids and derivatives
Amino acids, peptides, and analogues
PubChem CID
9900065
HMDB ID
HMDB0028888
Formula
C12H20N4O3
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
ChEBI ID
141437
ChemSpider ID
8075720
Physicochemical Properties Molecular Weight 268.31 Topological Polar Surface Area 121
XlogP -2.8 Complexity 324
Heavy Atom Count 19 Rotatable Bond Count 7
Hydrogen Bond Donor Count 4 Hydrogen Bond Acceptor Count 5
Function
Histidylisoleucine is a dipeptide composed of histidine and isoleucine. It is an incomplete breakdown product of protein digestion or protein catabolism. Dipeptides are organic compounds containing a sequence of exactly two alpha-amino acids joined by a peptide bond. Some dipeptides are known to have physiological or cell-signalling effects although most are simply short-lived intermediates on their way to specific amino acid degradation pathways following further proteolysis.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Pore-forming PNC peptide (PNC)
            Cellular tumor antigen p53 (TP53) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout of TP53
                      Induced Change Histidylisoleucine concentration: decrease (Log2 FC=0.72)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Colon cancer [ICD-11: 2B90]
                      Details It is reported that knockout of TP53 leads to the decrease of histidylisoleucine levels compared with control group.
References
1 Integrative omics analysis of p53-dependent regulation of metabolism. FEBS Lett. 2018 Feb;592(3):380-393.

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