Details of Metabolite

General Information of MET (ID: META00883)
Name Histidylglutamic acid
Synonyms   Click to Show/Hide Synonyms of This Metabolite
H-E dipeptide; HE; HE dipeptide; His-Glu; Histidine glutamic acid dipeptide; Histidine-glutamic acid dipeptide; Histidinyl-glutamate; Histidinyl-glutamic acid; Histidinylglutamate; Histidinylglutamic acid; Histidyl-glutamic acid; Histidylglutamate; Histidylglutamic acid; L-His-L-glu; L-Histidinyl-L-glutamate; L-Histidinyl-L-glutamic acid; L-Histidyl-L-glutamic acid; N-Histidinylglutamate; N-Histidinylglutamic acid; N-Histidylglutamate; N-Histidylglutamic acid; N-L-Histidinyl-L-glutamate; N-L-Histidinyl-L-glutamic acid; N-L-Histidyl-L-glutamate; N-L-Histidyl-L-glutamic acid
Source Aromatic heteromonocyclic compounds
Structure Type   Amino acids, peptides, and analogues  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic acids and derivatives
Carboxylic acids and derivatives
Amino acids, peptides, and analogues
PubChem CID
7010583
HMDB ID
HMDB0028884
Formula
C11H16N4O5
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
ChEBI ID
73928
ChemSpider ID
5374150
Physicochemical Properties Molecular Weight 284.27 Topological Polar Surface Area 158
XlogP -4 Complexity 376
Heavy Atom Count 20 Rotatable Bond Count 8
Hydrogen Bond Donor Count 5 Hydrogen Bond Acceptor Count 7
Function
Histidylglutamic acid is a dipeptide composed of histidine and glutamic acid. It is an incomplete breakdown product of protein digestion or protein catabolism. Dipeptides are organic compounds containing a sequence of exactly two alpha-amino acids joined by a peptide bond. Some dipeptides are known to have physiological or cell-signalling effects although most are simply short-lived intermediates on their way to specific amino acid degradation pathways following further proteolysis.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Pore-forming PNC peptide (PNC)
            Cellular tumor antigen p53 (TP53) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout of TP53
                      Induced Change Histidylglutamic acid concentration: increase (Log2 FC=1.55)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Colon cancer [ICD-11: 2B90]
                      Details It is reported that knockout of TP53 leads to the increase of histidylglutamic acid levels compared with control group.
References
1 Integrative omics analysis of p53-dependent regulation of metabolism. FEBS Lett. 2018 Feb;592(3):380-393.

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