Details of Metabolite

General Information of MET (ID: META00882)
Name Histidylaspartic acid
Synonyms   Click to Show/Hide Synonyms of This Metabolite
H-D dipeptide; HD; HD dipeptide; His-Asp; Histidine aspartate dipeptide; Histidine aspartic acid dipeptide; Histidine-aspartate dipeptide; Histidine-aspartic acid dipeptide; Histidinyl-aspartate; Histidinyl-aspartic acid; Histidinylaspartate; Histidinylaspartic acid; Histidyl-aspartate; Histidyl-aspartic acid; Histidylaspartate; Histidylaspartic acid; L-His-L-asp; L-Histidinyl-L-aspartate; L-Histidinyl-L-aspartic acid; L-Histidyl-L-aspartate; L-Histidyl-L-aspartic acid; N-Histidinylaspartate; N-Histidinylaspartic acid; N-Histidylaspartate; N-Histidylaspartic acid; N-L-Histidinyl-L-aspartate; N-L-Histidinyl-L-aspartic acid; N-L-Histidyl-L-aspartate; N-L-Histidyl-L-aspartic acid
Source Endogenous;Endogenous
Structure Type   Amino acids, peptides, and analogues  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic acids and derivatives
Carboxylic acids and derivatives
Amino acids, peptides, and analogues
PubChem CID
7020094
HMDB ID
HMDB0028881
Formula
C10H14N4O5
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
ChEBI ID
73925
ChemSpider ID
5383051
Physicochemical Properties Molecular Weight 270.24 Topological Polar Surface Area 158
XlogP -4.4 Complexity 362
Heavy Atom Count 19 Rotatable Bond Count 7
Hydrogen Bond Donor Count 5 Hydrogen Bond Acceptor Count 7
Function
Histidylaspartic acid is a dipeptide composed of histidine and aspartic acid. It is an incomplete breakdown product of protein digestion or protein catabolism. Dipeptides are organic compounds containing a sequence of exactly two alpha-amino acids joined by a peptide bond. Some dipeptides are known to have physiological or cell-signalling effects although most are simply short-lived intermediates on their way to specific amino acid degradation pathways following further proteolysis.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Pore-forming PNC peptide (PNC)
            Cellular tumor antigen p53 (TP53) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout of TP53
                      Induced Change Histidylaspartic acid concentration: decrease (Log2 FC=0.93)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Colon cancer [ICD-11: 2B90]
                      Details It is reported that knockout of TP53 leads to the decrease of histidylaspartic acid levels compared with control group.
References
1 Integrative omics analysis of p53-dependent regulation of metabolism. FEBS Lett. 2018 Feb;592(3):380-393.

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