General Information of MET (ID: META00878)
Name Arginylaspartic acid
Synonyms   Click to Show/Hide Synonyms of This Metabolite
Arg-asp; Arginine aspartate dipeptide; Arginine aspartic acid dipeptide; Arginine-aspartate dipeptide; Arginine-aspartic acid dipeptide; Arginyl-aspartate; Arginyl-aspartic acid; Arginylaspartate; Arginylaspartic acid; L-Arg-L-asp; L-Arginyl-L-aspartate; L-Arginyl-L-aspartic acid; N-Arginylaspartate; N-Arginylaspartic acid; N-L-Arginyl-L-aspartate; N-L-Arginyl-L-aspartic acid; R-D Dipeptide; RD; RD Dipeptide
Source Endogenous;Endogenous
Structure Type   Amino acids, peptides, and analogues  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic acids and derivatives
Carboxylic acids and derivatives
Amino acids, peptides, and analogues
PubChem CID
7009611
HMDB ID
HMDB0028705
Formula
C10H19N5O5
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
ChEBI ID
73812
Physicochemical Properties Molecular Weight 289.29 Topological Polar Surface Area 203
XlogP -4 Complexity 383
Heavy Atom Count 20 Rotatable Bond Count 7
Hydrogen Bond Donor Count 5 Hydrogen Bond Acceptor Count 5
Function
Arginylaspartic acid is a dipeptide composed of arginine and aspartic acid. It is an incomplete breakdown product of protein digestion or protein catabolism. Some dipeptides are known to have physiological or cell-signaling effects although most are simply short-lived intermediates on their way to specific amino acid degradation pathways following further proteolysis.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Pore-forming PNC peptide (PNC)
            Cellular tumor antigen p53 (TP53) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout of TP53
                      Induced Change Arginylaspartic acid concentration: decrease (Log2 FC=0.81)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Colon cancer [ICD-11: 2B90]
                      Details It is reported that knockout of TP53 leads to the decrease of arginylaspartic acid levels compared with control group.
References
1 Integrative omics analysis of p53-dependent regulation of metabolism. FEBS Lett. 2018 Feb;592(3):380-393.

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