General Information of MET (ID: META00877)
Name Arginylalanine
Synonyms   Click to Show/Hide Synonyms of This Metabolite
Arg-ala; Arginine alanine dipeptide; Arginine-alanine dipeptide; Arginyl-alanine; Arginylalanine; H-Arg-ala-OH; L-Arg-L-ala; L-Arginyl-L-alanine; N-Arginylalanine; N-L-Arginyl-L-alanine; R-a Dipeptide; RA; RA dipeptide
Source Endogenous;Endogenous
Structure Type   Amino acids, peptides, and analogues  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic acids and derivatives
Carboxylic acids and derivatives
Amino acids, peptides, and analogues
PubChem CID
7020333
HMDB ID
HMDB0028702
Formula
C9H19N5O3
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=7020333"></iframe>
3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
ChEBI ID
73810
Physicochemical Properties Molecular Weight 245.28 Topological Polar Surface Area 157
XlogP -4.5 Complexity 301
Heavy Atom Count 17 Rotatable Bond Count 7
Hydrogen Bond Donor Count 5 Hydrogen Bond Acceptor Count 5
Function
Arginylalanine is a dipeptide composed of arginine and alanine. It is an incomplete breakdown product of protein digestion or protein catabolism. Some dipeptides are known to have physiological or cell-signaling effects although most are simply short-lived intermediates on their way to specific amino acid degradation pathways following further proteolysis.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Pore-forming PNC peptide (PNC)
            Cellular tumor antigen p53 (TP53) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout of TP53
                      Induced Change Arginylalanine concentration: increase (Log2 FC=1.02)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Colon cancer [ICD-11: 2B90]
                      Details It is reported that knockout of TP53 leads to the increase of arginylalanine levels compared with control group.
References
1 Integrative omics analysis of p53-dependent regulation of metabolism. FEBS Lett. 2018 Feb;592(3):380-393.

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