Details of Metabolite

General Information of MET (ID: META00868)
Name MG(16:0/0:0/0:0)
Synonyms   Click to Show/Hide Synonyms of This Metabolite
(+-)-2,3-Dihydroxypropyl hexadecanoate; (1)-2,3-Dihydroxypropyl palmitate; (2S)-1-O-Hexadecanoylglycerol; (2S)-1-O-Palmitoylglycerol; (C16-C22)Trialkyl glyceride; (S)-1-Monopalmitin; (S)-2,3-Dihydroxypropyl N-hexadecanoate; (S)-2,3-Dihydroxypropyl N-hexadecanoic acid; (S)-2,3-Dihydroxypropyl palmitate; 1,2,3-Propanetriol 1-hexandecanoyl ester; 1-Glycerol hexadecanoates; 1-Glyceryl hexadecanoate; 1-Glyceryl monohexadecanoate; 1-Hexadecanoyl-sn-glycerol; 1-Hexadecanoylglycerol; 1-MONOPALMITOYL-rac-glycerol; 1-Monohexadecanoyl-rac-glycerol; 1-Monohexadecanoylglycerol; 1-Monopalmitin; 1-Monopalmitoylglycerol; 1-O-Hexadecanoylglycerol; 1-O-Palmitoyl-DL-glycerol; 1-O-Palmitoylglycerol; 1-Palmitoyl-rac-glycerol; 1-Palmitoylglycerol; 1-mono-Palmitin; 2,3-Dihydroxypropyl ester(.+/-.)-hexadecanoic acid; 2,3-Dihydroxypropyl hexadecanoate; 2,3-Dihydroxypropyl hexadecanoic acid; 2,3-Dihydroxypropyl palmitate; DL-1-Monopalmitin; DL-alpha-Palmitin; Glycerol 1-hexadecanoic acid; Glycerol 1-monohexadecanoate; Glycerol 1-monopalmitate; Glycerol 1-monopalmitic acid; Glycerol 1-palmitate; Glycerol 1-palmitic acid; Glycerol 3-palmitate; Glycerol 3-palmitic acid; Glycerol alpha -palmitate; Glycerol palmitate; Glyceryl monopalmitate; Glyceryl palmitate; Glyceryl palmitic acid; Hexadecanoate, 2,3-dihydroxypropyl ester; Hexadecanoic acid, 2,3-bishydroxy propyl ester; Hexadecanoic acid, 2,3-dihydroxypropyl ester; Hexadexanoic acid 2,3-dihydroxypropyl ester; L-(-)-alpha-Monopalmitin; MG (16:0/0:0/0:0); Monopalmitin; Palmitate a-monoglyceride; Palmitic acid alpha -monoglyceride; Palmitic acid alpha-monoglyceride; Palmitin, 1-mono; Palmitin, 1-mono- (8ci); Palmitoyl glycerol; Palmitoyl glycerol, (+,-)-isomer; Palmitoyl glycerol, hexadecanoic-1-(14)C-labeled CPD, (R)-isomer; alpha -Monopalmitin; alpha-Monopalmitin; rac-1(3)-Palmitoyl glycerol; rac-1-Palmitoylglycerol; rac-Glycerol 1-palmitate; sn-1-Palmitoylmonoglyceride; sn-1-Palmitoylmonoglycerol
Source Endogenous;Glycerolipids;Food
Structure Type   Monoradylglycerols  (Click to Show/Hide the Complete Structure Type Hierarchy)
Lipids and lipid-like molecules
Glycerolipids
Monoradylglycerols
PubChem CID
3084463
HMDB ID
HMDB0011564
Formula
C19H38O4
Structure
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3D MOL is unavailable 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
ChEBI ID
75542
FooDB ID
FDB028277
Physicochemical Properties Molecular Weight 330.5 Topological Polar Surface Area 66.8
XlogP 6.3 Complexity 256
Heavy Atom Count 23 Rotatable Bond Count 18
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 4
Function
MG(16:0/0:0/0:0) is a monoacylglyceride. A monoglyceride, more correctly known as a monoacylglycerol, is a glyceride consisting of one fatty acid chain covalently bonded to a glycerol molecule through an ester linkage. Monoacylglycerol can be broadly divided into two groups: 1-monoacylglycerols (or 3-monoacylglycerols) and 2-monoacylglycerols, depending on the position of the ester bond on the glycerol moiety. Normally the 1/3-isomers are not distinguished from each other and are termed 'alpha-monoacylglycerols', while the 2-isomers are beta-monoacylglycerols. Monoacylglycerols are formed biochemically via release of a fatty acid from diacylglycerol by diacylglycerol lipase or hormone sensitive lipase. Monoacylglycerols are broken down by monoacylglycerol lipase. They tend to be minor components only of most plant and animal tissues, and indeed would not be expected to accumulate because their strong detergent properties would have a disruptive effect on membranes. 2-Monoacylglycerols are a major end product of the intestinal digestion of dietary fats in animals via the enzyme pancreatic lipase. They are taken up directly by the intestinal cells and converted to triacylglycerols via the monoacylglycerol pathway before being transported in lymph to the liver. Mono- and diglycerides are commonly added to commercial food products in small quantities. They act as emulsifiers, helping to mix ingredients such as oil and water that would not otherwise blend well. MG(16:0/0:0/0:0), in particular, consists of one chain of palmitic acid at the C-1 position. MG(16:0/0:0/0:0) is a minor component of olive oil and other vegetable oil.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Pore-forming PNC peptide (PNC)
            Cellular tumor antigen p53 (TP53) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout of TP53
                      Induced Change MG(16:0/0:0/0:0) concentration: decrease (Log2 FC=0.27)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Colon cancer [ICD-11: 2B90]
                      Details It is reported that knockout of TP53 leads to the decrease of MG(16:0/0:0/0:0) levels compared with control group.
References
1 Integrative omics analysis of p53-dependent regulation of metabolism. FEBS Lett. 2018 Feb;592(3):380-393.

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