General Information of MET (ID: META00863)
Name Prolylglycine
Synonyms   Click to Show/Hide Synonyms of This Metabolite
L-Pro-gly; L-Prolinylglycine; L-Prolylglycine; N-L-Prolylglycine; N-Prolylglycine; NSC 89175; P-G; P-G dipeptide; PG; PG dipeptide; Pro-gly; Proline glycine dipeptide; Proline-glycine dipeptide; Prolyl-glycine; Prolylglycine
Source Endogenous;Escherichia Coli Metabolite;Food;Microbial
Structure Type   Amino acids, peptides, and analogues  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic acids and derivatives
Carboxylic acids and derivatives
Amino acids, peptides, and analogues
PubChem CID
6426709
HMDB ID
HMDB0011178
Formula
C7H12N2O3
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
ChEBI ID
61695
Physicochemical Properties Molecular Weight 172.18 Topological Polar Surface Area 78.4
XlogP -3 Complexity 193
Heavy Atom Count 12 Rotatable Bond Count 3
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 4
Function
Prolylglycine is a dipeptide composed of proline and glycine. It is an incomplete breakdown product of protein digestion or protein catabolism. Some dipeptides are known to have physiological or cell-signaling effects although most are simply short-lived intermediates on their way to specific amino acid degradation pathways following further proteolysis. It is found in urine.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Pore-forming PNC peptide (PNC)
            Cellular tumor antigen p53 (TP53) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout of TP53
                      Induced Change Prolylglycine concentration: increase (Log2 FC=1.02)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Colon cancer [ICD-11: 2B90]
                      Details It is reported that knockout of TP53 leads to the increase of prolylglycine levels compared with control group.
References
1 Integrative omics analysis of p53-dependent regulation of metabolism. FEBS Lett. 2018 Feb;592(3):380-393.

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