General Information of MET (ID: META00862)
Name Phenylalanylproline
Synonyms   Click to Show/Hide Synonyms of This Metabolite
1-(3-Phenyl-L-alanyl)-proline; 1-L-Phenylalanyl-L-proline; F-p Dipeptide; FP; FP Dipeptide; L-1-(3-Phenyl-L-alanyl)-proline; L-Phe-L-pro; L-Phenylalanyl-L-proline; Phe-pro; Phenylalanine proline dipeptide; Phenylalanine-proline dipeptide; Phenylalanyl-proline; Phenylalanylproline
Source Aromatic heteromonocyclic compounds
Structure Type   Amino acids, peptides, and analogues  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic acids and derivatives
Carboxylic acids and derivatives
Amino acids, peptides, and analogues
PubChem CID
7020641
HMDB ID
HMDB0011177
Formula
C14H18N2O3
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
ChEBI ID
74750
FooDB ID
FDB027949
ChemSpider ID
5383590
Physicochemical Properties Molecular Weight 262.3 Topological Polar Surface Area 88.1
XlogP -0.7 Complexity 334
Heavy Atom Count 19 Rotatable Bond Count 3
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 3
Function
Phenylalanylproline is a dipeptide composed of phenylalanine and proline. It is an incomplete breakdown product of protein digestion or protein catabolism. Some dipeptides are known to have physiological or cell-signaling effects although most are simply short-lived intermediates on their way to specific amino acid degradation pathways following further proteolysis. It is found in urine.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Pore-forming PNC peptide (PNC)
            Cellular tumor antigen p53 (TP53) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout of TP53
                      Induced Change Phenylalanylproline concentration: decrease (Log2 FC=0.67)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Colon cancer [ICD-11: 2B90]
                      Details It is reported that knockout of TP53 leads to the decrease of phenylalanylproline levels compared with control group.
References
1 Integrative omics analysis of p53-dependent regulation of metabolism. FEBS Lett. 2018 Feb;592(3):380-393.

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