Details of Metabolite

General Information of MET (ID: META00858)
Name Alanylglycine
Synonyms   Click to Show/Hide Synonyms of This Metabolite
(S)-Alanylglycine; AG; AG dipeptide; Ala-gly; Alanine glycine dipeptide; Alanine-glycine dipeptide; Alanyl-glycine; Alanylglycine; L-Ala-gly; L-Alanylglycine; N-Alanylglycine; N-L-Alanylglycine; NSC 89597; a-g Dipeptide
Source Endogenous;Food;Endogenous
Structure Type   Amino acids, peptides, and analogues  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic acids and derivatives
Carboxylic acids and derivatives
Amino acids, peptides, and analogues
PubChem CID
6998028
HMDB ID
HMDB0006899
Formula
C5H10N2O3
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=6998028"></iframe>
3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
ChEBI ID
73757
Physicochemical Properties Molecular Weight 146.14 Topological Polar Surface Area 96.9
XlogP -3 Complexity 140
Heavy Atom Count 10 Rotatable Bond Count 2
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 3
Function
Alanylglycine is a dipeptide composed of alanine and glycine that is found in human urine. It is a breakdown product from endogenous and exogenous proteins. This peptide is generated by dipeptidyl-dipeptidase (or tetrapeptide dipeptidase) which leads to the release of dipeptides from a tetrapeptide (more specifically: Ala-GlyAla-Gly). The enzyme acts more slowly on Ala-AlaAla-Ala and Gly-GlyGly-Gly.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Pore-forming PNC peptide (PNC)
            Cellular tumor antigen p53 (TP53) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout of TP53
                      Induced Change Alanylglycine concentration: decrease (Log2 FC=0.89)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Colon cancer [ICD-11: 2B90]
                      Details It is reported that knockout of TP53 leads to the decrease of alanylglycine levels compared with control group.
References
1 Integrative omics analysis of p53-dependent regulation of metabolism. FEBS Lett. 2018 Feb;592(3):380-393.

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