Details of Metabolite

General Information of MET (ID: META00855)
Name 3'-O-Methyladenosine
Synonyms   Click to Show/Hide Synonyms of This Metabolite
3'-O-Methyl-adenosine, 3'-O-Methyladenosine
Source Endogenous;Food
Structure Type   Purine nucleosides  (Click to Show/Hide the Complete Structure Type Hierarchy)
Nucleosides, nucleotides, and analogues
Purine nucleosides
PubChem CID
82530
HMDB ID
HMDB0006023
Formula
C11H15N5O4
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
FooDB ID
FDB023803
ChemSpider ID
74481
Physicochemical Properties Molecular Weight 281.27 Topological Polar Surface Area 129
XlogP -1.1 Complexity 349
Heavy Atom Count 20 Rotatable Bond Count 3
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 8
Function
3-O-Methyladenosine is a methylated adenine residue.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Pore-forming PNC peptide (PNC)
            Cellular tumor antigen p53 (TP53) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout of TP53
                      Induced Change 3'-O-Methyladenosine concentration: increase (Log2 FC=7.29)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Colon cancer [ICD-11: 2B90]
                      Details It is reported that knockout of TP53 leads to the increase of 3'-o-methyladenosine levels compared with control group.
References
1 Integrative omics analysis of p53-dependent regulation of metabolism. FEBS Lett. 2018 Feb;592(3):380-393.

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