General Information of MET (ID: META00846)
Name Glutamyllysine
Synonyms   Click to Show/Hide Synonyms of This Metabolite
E-K; EK; EK dipeptide; Glu-lys; Glutamate lysine dipeptide; Glutamate-lysine dipeptide; Glutamic acid lysine dipeptide; Glutamic acid-lysine dipeptide; Glutamyl-lysine; Glutamyllysine; L-Glu-L-lys; L-Glutamyl-L-lysine; L-a-Glutamyl-L-lysine; L-alpha-Glutamyl-L-lysine; N2-Glutamyllysine; N2-L-Glutamyl-L-lysine; N2-L-a-Glutamyl-lysine; N2-L-a-Glutamyllysine; N2-L-alpha-Glutamyl-L-lysine; N2-L-alpha-Glutamyl-lysine; N2-a-Glutamyl-lysine; N2-alpha-Glutamyl-lysine; N2-alpha-Glutamyllysine; N2-alpha-L-Glutamyl-L-lysine; alpha-Glu-lys; alpha-Glutamyllysine; alpha-L-Glu-L-lys; alpha-L-Glutamyl-L-lysine; e-K Dipeptide
Source Endogenous;Food
Structure Type   Amino acids, peptides, and analogues  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic acids and derivatives
Carboxylic acids and derivatives
Amino acids, peptides, and analogues
PubChem CID
7015704
HMDB ID
HMDB0004207
Formula
C11H21N3O5
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
ChEBI ID
73521
FooDB ID
FDB023334
ChemSpider ID
5378736
Physicochemical Properties Molecular Weight 275.3 Topological Polar Surface Area 156
XlogP -6.3 Complexity 322
Heavy Atom Count 19 Rotatable Bond Count 10
Hydrogen Bond Donor Count 5 Hydrogen Bond Acceptor Count 7
Function
Glutamyllysine is a dipeptide composed of glutamate and lysine, and is a proteolytic breakdown product of larger proteins. It belongs to the family of N-acyl-alpha amino acids and derivatives. These are compounds containing an alpha amino acid which bears an acyl group at its terminal nitrogen atom. Glutamyllysine is an incomplete breakdown product of protein digestion or protein catabolism. Some dipeptides are known to have physiological or cell-signaling effects although most are simply short-lived intermediates on their way to specific amino acid degradation pathways following further proteolysis. The absorption of glutamyllysine is facilitated by the human intestinal oligopeptide transporter (PEPT1).
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Pore-forming PNC peptide (PNC)
            Cellular tumor antigen p53 (TP53) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout of TP53
                      Induced Change Glutamyllysine concentration: decrease (Log2 FC=0.94)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Colon cancer [ICD-11: 2B90]
                      Details It is reported that knockout of TP53 leads to the decrease of glutamyllysine levels compared with control group.
References
1 Integrative omics analysis of p53-dependent regulation of metabolism. FEBS Lett. 2018 Feb;592(3):380-393.

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