General Information of MET (ID: META00841)
Name D-Proline
Synonyms   Click to Show/Hide Synonyms of This Metabolite
(2R)-Pyrrolidine-2-carboxylate; (2R)-Pyrrolidine-2-carboxylic acid; (R)-2-Carboxypyrrolidine; (R)-Pyrrolidine-2-carboxylate; (R)-Pyrrolidine-2-carboxylic acid; D-Prolin; DPR; Proline; R)-2-Carboxypyrrolidine; R-Proline
Source Endogenous;Yeast Metabolite;Food;Microbial
Structure Type   Amino acids, peptides, and analogues  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic acids and derivatives
Carboxylic acids and derivatives
Amino acids, peptides, and analogues
PubChem CID
8988
HMDB ID
HMDB0003411
Formula
C5H9NO2
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C00763
DrugBank ID
DB02853
ChEBI ID
16313
FooDB ID
FDB023166
ChemSpider ID
8640
Physicochemical Properties Molecular Weight 115.13 Topological Polar Surface Area 49.3
XlogP -2.5 Complexity 103
Heavy Atom Count 8 Rotatable Bond Count 1
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 3
Function
D-proline is an isomer of the naturally occurring amino acid, L-Proline. D-amino acids have been found in relatively high abundance in human plasma and saliva. These amino acids may be of bacterial origin, but there is also evidence that they are endogenously produced through amino acid racemase activity.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Pore-forming PNC peptide (PNC)
            Cellular tumor antigen p53 (TP53) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout of TP53
                      Induced Change D-Proline concentration: decrease (Log2 FC=0.57)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Colon cancer [ICD-11: 2B90]
                      Details It is reported that knockout of TP53 leads to the decrease of D-Proline levels compared with control group.
References
1 Integrative omics analysis of p53-dependent regulation of metabolism. FEBS Lett. 2018 Feb;592(3):380-393.

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