Details of Metabolite

General Information of MET (ID: META00832)
Name Galacturonic acid
Synonyms   Click to Show/Hide Synonyms of This Metabolite
(2S,3R,4S,5R)-2,3,4,5-Tetrahydroxy-6-oxohexanoate; (2S,3R,4S,5R)-2,3,4,5-Tetrahydroxy-6-oxohexanoic acid; (D)-Galacturonic acid; (DL)-Galacturonic acid; Aldehydo-D-galacturonate; Aldehydo-D-galacturonic acid; Anhydrogalacturonic acid; Calcium pectate; Calcium polygalacturonate; D-Galactopyranuronic acid; D-Galacturonate; D-Galacturonic acid; DL-Galacturonic acid; Galacturonan; Galacturonate; Galacturonic acid; Galacturonic acid, (D)-isomer; Galacturonic acid, (alpha-D)-isomer; Galacturonic acid, calcium, sodium salt, (D)-isomer; Galacturonic acid, monosodium salt, (D)-isomer; Homogalacturonan; Pectate; Pectic acid; Polygalacturonic acid; Polygalacturonic acid homopolymer; Polygalacturonic acid, aluminum salt; Polygalacturonic acid, calcium salt; Polygalacturonic acid, homopolymer (D)-isomer; Polygalacturonic acid, homopolymer sodium salt; Polygalacturonic acid, sulfated; Sodium pectate; Sodium polygalacturonate
Source Endogenous;Drug;Escherichia Coli Metabolite;Food;Plant Metabolite
Structure Type   Carbohydrates and carbohydrate conjugates  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic oxygen compounds
Organooxygen compounds
Carbohydrates and carbohydrate conjugates
PubChem CID
84740
HMDB ID
HMDB0002545
Formula
C6H10O7
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C08348
ChEBI ID
47962
FooDB ID
FDB001160
ChemSpider ID
76444
METLIN ID
6713
Physicochemical Properties Molecular Weight 194.14 Topological Polar Surface Area 135
XlogP -2.6 Complexity 191
Heavy Atom Count 13 Rotatable Bond Count 5
Hydrogen Bond Donor Count 5 Hydrogen Bond Acceptor Count 7
Function
D-Galacturonic acid is a sugar acid, the oxidized form of D-galactose. It is the main component of pectin, in which it exists as the polymer polygalacturonic acid. -- Wikipedia.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Pore-forming PNC peptide (PNC)
            Cellular tumor antigen p53 (TP53) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout of TP53
                      Induced Change Galacturonic acid concentration: decrease (Log2 FC=0.95)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Colon cancer [ICD-11: 2B90]
                      Details It is reported that knockout of TP53 leads to the decrease of galacturonic acid levels compared with control group.
References
1 Integrative omics analysis of p53-dependent regulation of metabolism. FEBS Lett. 2018 Feb;592(3):380-393.

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