Details of Metabolite

General Information of MET (ID: META00831)
Name 2,4-Diaminobutyric acid
Synonyms   Click to Show/Hide Synonyms of This Metabolite
(RS)-2,4-Diaminobutyric acid; 2,4-Diamino-N-butyric acid; 2,4-Diamino-butanoate; 2,4-Diamino-butanoic acid; 2,4-Diamino-butyrate; 2,4-Diamino-butyric acid; 2,4-Diaminobutanoate; 2,4-Diaminobutanoic acid; 2,4-Diaminobutyrate; 2,4-Diaminobutyric acid; 2,4-Diaminobutyric acid dihydrochloride, (+-)-isomer; 2,4-Diaminobutyric acid dihydrochloride, (S)-isomer; 2,4-Diaminobutyric acid monohydrochloride, (+-)-isomer; 2,4-Diaminobutyric acid monohydrochloride, (S)-isomer; 2,4-Diaminobutyric acid, (+)-isomer; 2,4-Diaminobutyric acid, (+-)-isomer; 2,4-Diaminobutyric acid, (R)-isomer; 2,4-Diaminobutyric acid, (S)-isomer; DL-2,4-Diamino-N-butyric acid; DL-2,4-Diaminobutanoate; DL-2,4-Diaminobutanoic acid; DL-2,4-Diaminobutyric acid; DL-alpha,gamma-Diaminobutyric acid; Dbu; L-2,4-Diaminobutyric acid; a,g-Diaminobutanoate; a,g-Diaminobutanoic acid; a,g-Diaminobutyrate; a,g-Diaminobutyric acid; alpha,gamma-Diaminobutanoic acid; alpha,gamma-Diaminobutyric acid
Source Escherichia Coli Metabolite;Fatty acyls;Food;Microbial
Structure Type   Amino acids, peptides, and analogues  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic acids and derivatives
Carboxylic acids and derivatives
Amino acids, peptides, and analogues
PubChem CID
470
HMDB ID
HMDB0002362
Formula
C4H10N2O2
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
ChEBI ID
64307
FooDB ID
FDB022978
ChemSpider ID
457
Physicochemical Properties Molecular Weight 118.13 Topological Polar Surface Area 89.3
XlogP -4.6 Complexity 84.1
Heavy Atom Count 8 Rotatable Bond Count 3
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 4
Function
2,4-Diaminobutyric acid is a non-physiological, cationic amino acid analogue that is transported into cells by System A with potent antitumoral activity in vitro against human glioma cells, the result of the pronounced concentrated uptake of DAB in glioma cells to the extent that a cellular lysis could occur due to osmotic reasons.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Pore-forming PNC peptide (PNC)
            Cellular tumor antigen p53 (TP53) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout of TP53
                      Induced Change 2,4-Diaminobutyric acid concentration: decrease (Log2 FC=0.61)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Colon cancer [ICD-11: 2B90]
                      Details It is reported that knockout of TP53 leads to the decrease of 2,4-diaminobutyric acid levels compared with control group.
References
1 Integrative omics analysis of p53-dependent regulation of metabolism. FEBS Lett. 2018 Feb;592(3):380-393.

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