Details of Metabolite

General Information of MET (ID: META00816)
Name Folinic acid
Synonyms   Click to Show/Hide Synonyms of This Metabolite
(6S)-5-Formyl-5,6,7,8-tetrahydrofolate; (6S)-5-Formyl-5,6,7,8-tetrahydrofolic acid; (6S)-5-Formyltetrahydrofolate; (6S)-5-Formyltetrahydrofolic acid; (6S)-Folinate; (6S)-Folinic acid; (6S)-Leucovorin; (S)-Leucovorin; 5 Formyltetrahydrofolate; 5 Formyltetrahydropteroylglutamate; 5-Formyl-(6S)-tetrahydrofolic acid; 5-Formyl-5,6,7,8-tetrahydrofolic acid; 5-Formyltetrahydrofolate; 5-Formyltetrahydrofolic acid; 5-Formyltetrahydropteroylglutamate; 5-Formyltetrahydropteroylglutamic acid; 6 S Leucovorin; 6-S-Leucovorin; 6S Leucovorin; 6S-Leucovorin; Acid, folinic; CF; Calcium folinate; Calcium leucovorin; Citrovorum factor; Factor, citrovorum; Folinate; Folinate, calcium; Folinic acid; Folinic acid SF; Folinic acid-SF; Fusilev; Kunyrin; L-Folinate; L-Folinic acid; Leucoverin; Leucovorin; Leucovorin, (D)-isomer; Leucovorin, (DL)-isomer; Leucovorin, (R)-isomer; Leucovorin, (S)-isomer; Leucovorin, calcium; Leucovorin, calcium (1:1) salt; Leucovorin, calcium (1:1) salt, (DL)-isomer; Leucovorin, calcium (1:1) salt, (S)-isomer; Leucovorin, calcium (1:1) salt, pentahydrate; Leucovorin, monopotassium salt, (S)-isomer; Leucovorin, monosodium salt; Leucovorin, monosodium salt, (S)-isomer; Leukovorin; Leukovorum; Levo leucovorin; Levo-leucovorin; Levofolene; Levofolinate; Levofolinic acid; Levoleucovorin; Monosodium salt leucovorin; N(5)-Formyltetrahydrofolate; N-[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamate; N-[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid; N5-Formyl-5,6,7,8-tetrahydrofolic acid; N5-Formyl-THF; N5-Formyltetrahydrofolic acid; Pteroyl-D-glutamate; S Leucovorin; S-Leucovorin; Welcovorin; Wellcovorin
Source Endogenous;Escherichia Coli Metabolite;Yeast Metabolite;Food;Microbial
Structure Type   Pterins and derivatives  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organoheterocyclic compounds
Pteridines and derivatives
Pterins and derivatives
PubChem CID
149436
HMDB ID
HMDB0001562
Formula
C20H23N7O7
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C03479
DrugBank ID
DB11596
ChEBI ID
63606
FooDB ID
FDB022689
ChemSpider ID
131714
Physicochemical Properties Molecular Weight 473.4393 Topological Polar Surface Area N.A.
XlogP N.A. Complexity N.A.
Heavy Atom Count N.A. Rotatable Bond Count N.A.
Hydrogen Bond Donor Count N.A. Hydrogen Bond Acceptor Count N.A.
Function
Folinic acid (CAS: 58-05-9), also known as leucovorin, is a medication used to decrease the toxic effects of methotrexate (a chemotherapy agent and immune system suppressant) and pyrimethamine. Folinic acid is the active metabolite of folic acid. Leucovorin is used principally as its calcium salt as an antidote to folic acid antagonists which block the conversion of folic acid to folinic acid.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Pore-forming PNC peptide (PNC)
            Cellular tumor antigen p53 (TP53) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout of TP53
                      Induced Change Folinic acid concentration: decrease (Log2 FC=0.86)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Colon cancer [ICD-11: 2B90]
                      Details It is reported that knockout of TP53 leads to the decrease of folinic acid levels compared with control group.
References
1 Integrative omics analysis of p53-dependent regulation of metabolism. FEBS Lett. 2018 Feb;592(3):380-393.

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