Details of Metabolite

General Information of MET (ID: META00809)
Name 1-Deoxy-D-xylulose 5-phosphate
Synonyms   Click to Show/Hide Synonyms of This Metabolite
1-Deoxy-D-threo-pentulose 5-phosphate; 1-Deoxy-D-xylulose 5-phosphoric acid; 1-Deoxylulose 5-phosphate; D-1-Deoxyxylulose-5-p; DOXP; DXP; Deoxyxylulose-5-phosphate
Source Endogenous;Escherichia Coli Metabolite;Food;Drug;Microbial
Structure Type   Carbohydrates and carbohydrate conjugates  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic oxygen compounds
Organooxygen compounds
Carbohydrates and carbohydrate conjugates
PubChem CID
443201
HMDB ID
HMDB0001213
Formula
C5H11O7P
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=443201"></iframe>
3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C11437
DrugBank ID
DB02496
ChEBI ID
16493
FooDB ID
FDB022494
ChemSpider ID
391473
METLIN ID
6085
Physicochemical Properties Molecular Weight 214.11 Topological Polar Surface Area 124
XlogP -3.1 Complexity 221
Heavy Atom Count 13 Rotatable Bond Count 5
Hydrogen Bond Donor Count 4 Hydrogen Bond Acceptor Count 7
Function
1-Deoxy-D-xylulose 5-phosphate is a substrate for 2,4-dienoyl-CoA reductase (mitochondrial). It has been found to be a metabolite of Escherichia and Streptomyces.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Pore-forming PNC peptide (PNC)
            Cellular tumor antigen p53 (TP53) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout of TP53
                      Induced Change 1-Deoxy-D-xylulose 5-phosphate concentration: increase (Log2 FC=1.43)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Colon cancer [ICD-11: 2B90]
                      Details It is reported that knockout of TP53 leads to the increase of 1-deoxy-D-xylulose 5-phosphate levels compared with control group.
References
1 Integrative omics analysis of p53-dependent regulation of metabolism. FEBS Lett. 2018 Feb;592(3):380-393.

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