General Information of MET (ID: META00805)
Name N-Acetylmannosamine
Synonyms   Click to Show/Hide Synonyms of This Metabolite
2-Acetamido-2-deoxy-D-mannopyranose; 2-Acetamido-2-deoxy-D-mannose; ManNAc; N-Acetyl-D-mannosamine; N-Acetyl-beta-mannosamine; N-Acetylmannosamine, (D)-isomer; N-Acetylmannosamine, (L)-isomer; beta-ManNAc
Source Endogenous;Escherichia Coli Metabolite;Food
Structure Type   Carbohydrates and carbohydrate conjugates  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic oxygen compounds
Organooxygen compounds
Carbohydrates and carbohydrate conjugates
PubChem CID
11096158
HMDB ID
HMDB0001129
Formula
C8H15NO6
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C00645
ChEBI ID
63154
FooDB ID
FDB028419
ChemSpider ID
9271300
METLIN ID
6024
Physicochemical Properties Molecular Weight 221.21 Topological Polar Surface Area 119
XlogP -1.7 Complexity 235
Heavy Atom Count 15 Rotatable Bond Count 2
Hydrogen Bond Donor Count 5 Hydrogen Bond Acceptor Count 6
Function
N-Acetylmannosamine is a monosaccharide that is used as a precursor in the chemical or enzymatic synthesis of the neuraminic acids found in glycolipids and glycoproteins. N-Acetyl-D-mannosamine (ManNAc) is a specific substrate for the synthesis of N-acetylneuraminic acid, the essential precursor of bacterial capsular polysialic acid (PA). N-Acetyl-D-mannosamine is used for the synthesis of sialic acid. It is also a synthetic intermediate for a number of carbohydrate-derived families of biologically active compounds and pharmaceutical candidates. N-Acetylmannosamine is a microbial metabolite of Escherichia.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Pore-forming PNC peptide (PNC)
            Cellular tumor antigen p53 (TP53) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout of TP53
                      Induced Change N-Acetylmannosamine concentration: decrease (Log2 FC=0.96)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Colon cancer [ICD-11: 2B90]
                      Details It is reported that knockout of TP53 leads to the decrease of N-acetylmannosamine levels compared with control group.
References
1 Integrative omics analysis of p53-dependent regulation of metabolism. FEBS Lett. 2018 Feb;592(3):380-393.

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