Details of Metabolite

General Information of MET (ID: META00803)
Name N-Acetyl-D-Glucosamine 6-Phosphate
Synonyms   Click to Show/Hide Synonyms of This Metabolite
2-Acetamido-2-deoxy-6-O-phosphono-D-glucopyranose; GlcNAc6p; N-Acetyl-D-glucosamine 6-phosphoric acid; N-Acetyl-D-glucosamine-6-p; N-Acetyl-D-glucosamine-6-phosphate; N-Acetyl-glucosamine-6-p; N-Acetyl-glucosamine-6-phosphate; N-Acetylglucosamine 6-phosphate; N-Acetylglucosamine-6-p
Source Endogenous;Escherichia Coli Metabolite;Yeast Metabolite;Food;Microbial
Structure Type   Carbohydrates and carbohydrate conjugates  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic oxygen compounds
Organooxygen compounds
Carbohydrates and carbohydrate conjugates
PubChem CID
440996
HMDB ID
HMDB0001062
Formula
C8H16NO9P
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C00357
DrugBank ID
DB03951
ChEBI ID
15784
FooDB ID
FDB022401
ChemSpider ID
389821
METLIN ID
5975
Physicochemical Properties Molecular Weight 301.19 Topological Polar Surface Area 166
XlogP -4.2 Complexity 371
Heavy Atom Count 19 Rotatable Bond Count 4
Hydrogen Bond Donor Count 6 Hydrogen Bond Acceptor Count 9
Function
N-Acetyl-D-Glucosamine 6-Phosphate is an intermediate in the metabolism of Aminosugars. It is a substrate for Glucosamine 6-phosphate N-acetyltransferase.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Pore-forming PNC peptide (PNC)
            Cellular tumor antigen p53 (TP53) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout of TP53
                      Induced Change N-Acetyl-D-Glucosamine 6-Phosphate concentration: increase (Log2 FC=1.51)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Colon cancer [ICD-11: 2B90]
                      Details It is reported that knockout of TP53 leads to the increase of N-acetyl-D-glucosamine 6-phosphate levels compared with control group.
References
1 Integrative omics analysis of p53-dependent regulation of metabolism. FEBS Lett. 2018 Feb;592(3):380-393.

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