| General Information of MET (ID: META00802) |
| Name |
Gamma-Glutamylcysteine
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| Synonyms |
Click to Show/Hide Synonyms of This Metabolite
5-L-Glutamyl-L-cysteine; 5-L-Glutamylcysteine; H-gamma-Glu-Cys-OH; L-gamma-Glutamyl-L-cysteine; L-gamma-Glutamylcysteine; N-L-gamma-Glutamyl-L-cysteine; N-L-gamma-Glutamylcysteine; N-gamma-Glutamylcysteine; g-Glu-Cys; g-Glutamylcysteine; g-L-Glutamyl-L-cysteine; gamma-Glu-Cys; gamma-Glutamylcysteine; gamma-L-Glu-L-Cys; gamma-L-Glutamyl-L-cysteine
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| Source |
Endogenous;Escherichia Coli Metabolite;Yeast Metabolite;Food;Drug;TCM Ingredients;Microbial
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| Structure Type |
Amino acids, peptides, and analogues (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic acids and derivatives
Carboxylic acids and derivatives
Amino acids, peptides, and analogues
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| PubChem CID |
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| HMDB ID |
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| Formula |
C8H14N2O5S
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| Structure |
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=123938"></iframe>
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3D MOL
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2D MOL
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Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
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| KEGG ID |
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| DrugBank ID |
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| ChEBI ID |
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| FooDB ID |
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| METLIN ID |
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| Physicochemical Properties |
Molecular Weight |
250.27 |
Topological Polar Surface Area |
131 |
| XlogP |
-3.8 |
Complexity |
284 |
| Heavy Atom Count |
16 |
Rotatable Bond Count |
7 |
| Hydrogen Bond Donor Count |
5 |
Hydrogen Bond Acceptor Count |
7 |
| Function |
gamma-Glutamylcysteine is a dipeptide composed of gamma-glutamate and cysteine, and is a proteolytic breakdown product of larger proteins. It belongs to the family of N-acyl-alpha amino acids and derivatives. These are compounds containing an alpha amino acid which bears an acyl group at its terminal nitrogen atom. gamma-Glutamylcysteine is an incomplete breakdown product of protein digestion or protein catabolism. Some dipeptides are known to have physiological or cell-signaling effects although most are simply short-lived intermediates on their way to specific amino acid degradation pathways following further proteolysis. gamma-Glutamylcysteine is a product of enzyme glutamate-cysteine ligase [EC 6.3.2.2] and a substrate of enzyme glutathione synthase [EC 6.3.2.3] in the glutamate metabolism pathway (KEGG).
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Regulatory Network
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Induced Change