Details of Metabolite

General Information of MET (ID: META00800)
Name Deoxyribose 5-phosphate
Synonyms   Click to Show/Hide Synonyms of This Metabolite
2-Deoxy-D-ribose 5-phosphate; 2-Deoxy-D-ribose-5-phosphate; 2-Deoxy-alpha-D-ribose 5-phosphate; 2-Deoxy-alpha-delta-ribose 5-phosphate; 2-Deoxyribose 5-phosphate; 2-Deoxyribose-5-p; 2-Deoxyribose-5-phosphate; Deoxy-ribose-5P; Deoxyribose 5-phosphoric acid; Deoxyribose-5-p; Deoxyribose-5-phosphate
Source Endogenous;Escherichia Coli Metabolite;Yeast Metabolite;Food;Microbial
Structure Type   Carbohydrates and carbohydrate conjugates  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic oxygen compounds
Organooxygen compounds
Carbohydrates and carbohydrate conjugates
PubChem CID
45934311
HMDB ID
HMDB0001031
Formula
C5H11O7P
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C00673
ChEBI ID
16132
FooDB ID
FDB022380
ChemSpider ID
25057464
METLIN ID
5956
Physicochemical Properties Molecular Weight 214.11 Topological Polar Surface Area 116
XlogP -2.6 Complexity 213
Heavy Atom Count 13 Rotatable Bond Count 3
Hydrogen Bond Donor Count 4 Hydrogen Bond Acceptor Count 7
Function
Deoxyribose 5-phosphate is a a metabolite in the pentose phosphate pathway. It can be generated from D-glyceraldehdye-3 phosphate via the enzyme 2-Deoxyribose 5-phosphate aldolase (DERA). Alternately Deoxyribose 5-phosphate can be converted to D-glyceraldehyde-3 phosphate that can then feed into the pentose phosphate pathway. Deoxyribose 5-phosphate can also be generated from 2-Deoxy-D-ribose via the enzyme Ribokinase (EC 2.7.1.15). It has been shown in a number of organisms that deoxynucleosides or deoxyriboses cause the induction of aldolases (such as DERA) involved in their catabolism, leading to the utilisation of the pentose moiety as carbon and energy source.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Pore-forming PNC peptide (PNC)
            Cellular tumor antigen p53 (TP53) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout of TP53
                      Induced Change Deoxyribose 5-phosphate concentration: increase (Log2 FC=1.07)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Colon cancer [ICD-11: 2B90]
                      Details It is reported that knockout of TP53 leads to the increase of deoxyribose 5-phosphate levels compared with control group.
References
1 Integrative omics analysis of p53-dependent regulation of metabolism. FEBS Lett. 2018 Feb;592(3):380-393.

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