Details of Metabolite

General Information of MET (ID: META00796)
Name Ribothymidine
Synonyms   Click to Show/Hide Synonyms of This Metabolite
1-(beta-D-Ribofuranosyl)thymine; 1-b-D-Ribofuranosylthymine; 1-beta-delta-Ribofuranosylthymine; 5-Methyl-1-beta-D-ribofuranosyl-2,4(1H,3H)-pyrimidinedione; 5-Methyl-1-beta-delta-ribofuranosyl-2,4(1H,3H)-pyrimidinedione; 5-Methyl-uridine; 5-Methyluridine; Ribosylthymidine; Ribosylthymine; Thymine ribofuranoside; Thymine ribonucleoside; Thymine riboside; Thymine-1 beta-D-ribofuranosylthymine; Thymine-1 beta-delta-ribofuranosylthymine; b-D-Ribofuranoside thymine-1; beta-D-Ribofuranoside; beta-delta-Ribofuranoside; beta-delta-Ribofuranoside thymine-1; t
Source Endogenous;Escherichia Coli Metabolite;Food;Microbial
Structure Type   Pyrimidine nucleosides  (Click to Show/Hide the Complete Structure Type Hierarchy)
Nucleosides, nucleotides, and analogues
Pyrimidine nucleosides
PubChem CID
445408
HMDB ID
HMDB0000884
Formula
C10H14N2O6
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=445408"></iframe>
3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
ChEBI ID
45996
FooDB ID
FDB022298
ChemSpider ID
393058
METLIN ID
5843
Physicochemical Properties Molecular Weight 258.23 Topological Polar Surface Area 119
XlogP -1.6 Complexity 409
Heavy Atom Count 18 Rotatable Bond Count 2
Hydrogen Bond Donor Count 4 Hydrogen Bond Acceptor Count 6
Function
Ribothymidine is an endogenous methylated nucleoside found in human fluids; methylated purine bases are present in higher amounts in tumor-bearing patients compared to healthy controls.DNA hypermethylation is a common finding in malignant cells and has been explored as a therapeutic target for hypomethylating agents. When chemical bonds to DNA, the DNA becomes damaged and proper and complete replication cannot occur to make the normal intended cell. A DNA adduct is an abnormal piece of DNA covalently-bonded to a cancer-causing chemical. This has shown to be the start of a cancerous cell, or carcinogenesis. DNA adducts in scientific experiments are used as bio-markers and as such are themselves measured to reflect quantitatively, for comparison, the amount of cancer in the subject.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Pore-forming PNC peptide (PNC)
            Cellular tumor antigen p53 (TP53) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout of TP53
                      Induced Change Ribothymidine concentration: decrease (Log2 FC=0.35)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Colon cancer [ICD-11: 2B90]
                      Details It is reported that knockout of TP53 leads to the decrease of ribothymidine levels compared with control group.
References
1 Integrative omics analysis of p53-dependent regulation of metabolism. FEBS Lett. 2018 Feb;592(3):380-393.

If you find any error in data or bug in web service, please kindly report it to Dr. Zhang and Dr. Mou.