General Information of MET (ID: META00795)
Name Salicyluric acid
Synonyms   Click to Show/Hide Synonyms of This Metabolite
((2-Hydroxybenzoyl)amino)acetic acid; (2-Hydroxybenzoyl)glycine; 2-Hydroxybenzoylaminoacetate; 2-Hydroxybenzoylaminoacetic acid; 2-Hydroxybenzoylglycine; 2-Hydroxyhippurate; 2-Hydroxyhippuric acid; N-(2-Hydroxybenzoyl)-glycine; N-(2-Hydroxybenzoyl)glycine; N-(O-Hydroxybenzoyl)glycine; N-O-Hydroxybenzoylglycine; N-Salicyloylglycine; O-Hydroxy-hippurate; O-Hydroxy-hippuric acid; O-Hydroxyhippate; O-Hydroxyhippic acid; O-Hydroxyhippurate; O-Hydroxyhippuric acid; Ortho-hydroxyhippurate; Ortho-hydroxyhippuric acid; Salicylate; Salicylglycine; Salicylic acid; Salicyloylglycine; Salicylurate; Salicylurate, monosodium salt; Salicyluric acid; [(2-Hydroxybenzoyl)amino]acetate; [(2-Hydroxybenzoyl)amino]acetic acid
Source Endogenous;Yeast Metabolite;Food;Microbial
Structure Type   Benzoic acids and derivatives  (Click to Show/Hide the Complete Structure Type Hierarchy)
Benzenoids
Benzene and substituted derivatives
Benzoic acids and derivatives
PubChem CID
10253
HMDB ID
HMDB0000840
Formula
C9H9NO4
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C07588
ChEBI ID
9008
FooDB ID
FDB010505
ChemSpider ID
9835
METLIN ID
617
Physicochemical Properties Molecular Weight 195.17 Topological Polar Surface Area 86.6
XlogP 0.9 Complexity 229
Heavy Atom Count 14 Rotatable Bond Count 3
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 4
Function
Salicyluric acid is an aryl glycine conjugate formed by the body to eliminate excess salicylates, including aspirin. Aspirin is rapidly hydrolysed to salicylic acid which is further metabolized to various compounds, including salicyluric acid (SU) as well as various acyl and phenolic glucuronides, and hydroxylated metabolites. SU is the major metabolite of SA excreted in urine and it is present in the urine of people who have not taken salicylate drugs, although it has no anti-inflammatory effects in humans or in animals. More salicyluric acid (SU) is excreted in the urine of vegetarians than in non-vegetarians, primarily because fruits and vegetables are important sources of dietary salicylates. However, significantly less (10-15X) SU is excreted by vegetarians than individuals taking low-dose aspirin. The induction of the salicyluric acid formation is one of the saturable pathways of salicylate elimination. The formation of the methyl ester of salicyluric acid is observed during the quantitation of salicyluric acid and other salicylate metabolites in urine by high-pressure liquid chromatography. This methyl ester formation causes artificially low values for salicyluric acid and high values for salicylic acid. Salicyluric acid has been found to be a microbial metabolite.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Pore-forming PNC peptide (PNC)
            Cellular tumor antigen p53 (TP53) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout of TP53
                      Induced Change Salicyluric acid concentration: increase (Log2 FC=1.04)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Colon cancer [ICD-11: 2B90]
                      Details It is reported that knockout of TP53 leads to the increase of salicyluric acid levels compared with control group.
References
1 Integrative omics analysis of p53-dependent regulation of metabolism. FEBS Lett. 2018 Feb;592(3):380-393.

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