Details of Metabolite

General Information of MET (ID: META00789)
Name Galactose 1-phosphate
Synonyms   Click to Show/Hide Synonyms of This Metabolite
1-(Dihydrogen phosphate) galactitol; 1-O-Phosphono-alpha-D-galactopyranose; 1-Phosphate a-D-galactopyranose; D-Galactopyranose 1-phosphate; D-Galactopyranose 1-phosphoric acid; D-Galactose 1-phosphate; D-Galactose 1-phosphoric acid; Galactopyranose 1-phosphate; Galactose 1-phosphoric acid; Galactose-1-phosphate; Galactose-1-phosphate, (beta-D-gal)-isomer; Galactose-1-phosphate, (beta-L-gal)-isomer; Galactose-1-phosphate, 14C-labeled; Galactose-1-phosphate, disilver (+1) salt, (D-gal)-isomer; Galactose-1-phosphate, sodium salt; Galactose-1-phosphoric acid; a-D-1-(Dihydrogen phosphate) galactopyranose; a-D-Galactopyranose 1-phosphate; a-D-Galactopyranose 1-phosphoric acid; a-D-Galactopyranose, 1-(dihydrogen phosphate); a-D-Galactopyranose, 1-(dihydrogen phosphoric acid); a-D-Galactopyranosyl phosphate; a-D-Galactopyranosyl phosphoric acid; a-D-Galactose 1-phosphate; a-D-Galactose-1-phosphate; a-D-Galactose-1-phosphoric acid; a-D-Galactosyl phosphate; a-D-Galactosyl phosphoric acid; alpha-D-1-(Dihydrogen phosphate) galactopyranose; alpha-D-Gal-1-p; alpha-D-Galactopyranose 1-phosphate; alpha-D-Galactopyranose, 1-(dihydrogen phosphate); alpha-D-Galactopyranosyl phosphate; alpha-D-Galactose 1-phosphate; alpha-D-Galactosyl phosphate
Source Endogenous;Escherichia Coli Metabolite;Yeast Metabolite;Food
Structure Type   Carbohydrates and carbohydrate conjugates  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic oxygen compounds
Organooxygen compounds
Carbohydrates and carbohydrate conjugates
PubChem CID
123912
HMDB ID
HMDB0000645
Formula
C6H13O9P
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C00446
DrugBank ID
DB02317
ChEBI ID
17973
FooDB ID
FDB031262
Physicochemical Properties Molecular Weight 260.14 Topological Polar Surface Area 157
XlogP -3.8 Complexity 277
Heavy Atom Count 16 Rotatable Bond Count 3
Hydrogen Bond Donor Count 6 Hydrogen Bond Acceptor Count 9
Function
Galactose 1-phosphate is classified as a member of the monosaccharide phosphates. Monosaccharide phosphates are monosaccharides comprising a phosphated group linked to the carbohydrate unit. Galactose 1-phosphate is an intermediate in the galactose metabolism and nucleotide sugars metabolism pathways (KEGG). It is formed from galactose by galactokinase. (Wikipeida). Galactose 1-phosphate is considered to be soluble (in water) and acidic.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Pore-forming PNC peptide (PNC)
            Cellular tumor antigen p53 (TP53) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout of TP53
                      Induced Change Galactose 1-phosphate concentration: decrease (Log2 FC=0.82)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Colon cancer [ICD-11: 2B90]
                      Details It is reported that knockout of TP53 leads to the decrease of galactose 1-phosphate levels compared with control group.
References
1 Integrative omics analysis of p53-dependent regulation of metabolism. FEBS Lett. 2018 Feb;592(3):380-393.

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