| General Information of MET (ID: META00777) |
| Name |
2-Hydroxyadenine
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| Synonyms |
Click to Show/Hide Synonyms of This Metabolite
2-Hydroxy-6-aminopurine; 2-Hydroxyadenine; 2-OH-Ade; 2-Oxoadenine; 2-Oxyadenine; 6-Amino-1,3-dihydro-2H-purin-2-one; 6-Amino-2-hydroxypurine; 6-Amino-3,7(9)-dihydro-purin-2-one; 6-Amino-3,7-dihydro-purin-2-one; 6-Amino-3,9-dihydro-2H-purin-2-one; 6-Amino-7H-purin-2-ol; 6-Amino-9H-purin-2-ol; Crotonoside; Isoguanine
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| Source |
Endogenous;Food;TCM Ingredients
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| Structure Type |
Purines and purine derivatives (Click to Show/Hide the Complete Structure Type Hierarchy)
Organoheterocyclic compounds
Imidazopyrimidines
Purines and purine derivatives
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| PubChem CID |
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| HMDB ID |
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| Formula |
C5H5N5O
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| Structure |
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=76900"></iframe>
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3D MOL
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2D MOL
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Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
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| ChEBI ID |
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| FooDB ID |
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| ChemSpider ID |
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| METLIN ID |
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| Physicochemical Properties |
Molecular Weight |
151.13 |
Topological Polar Surface Area |
91.9 |
| XlogP |
-1.7 |
Complexity |
313 |
| Heavy Atom Count |
11 |
Rotatable Bond Count |
N.A. |
| Hydrogen Bond Donor Count |
3 |
Hydrogen Bond Acceptor Count |
2 |
| Function |
2-Hydroxyadenine (2-OH-Ade) is formed by hydroxyl radical attack on DNA bases and shows a genotoxicity in human, being the source of the mutations induced by reactive oxygen species. 2-OH-Ade in DNA is miscoding and elicits various mutations, and is a mutagenic in bacterial and mammalian cells. (Recent Research Developments in Biochemistry (2000)2:41-50).
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Regulatory Network
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Induced Change
