Details of Metabolite

General Information of MET (ID: META00766)
Name Dihomo-gamma-linolenoylcholine
Synonyms   Click to Show/Hide Synonyms of This Metabolite
Choline dihomo-gamma-linolenate; Choline dihomo-gamma-linolenic acid; Choline dihomolinolenate; Choline dihomolinolenic acid; Dihomo-gamma-linolenoyl-choline; Dihomo-gamma-linolenoylcholine; Dihomo-linolenoyl-choline; Dihomolinolenoyl-choline; Dihomolinolenoylcholine
Source Aliphatic acyclic compounds
Structure Type   Quaternary ammonium salts  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic nitrogen compounds
Organonitrogen compounds
Quaternary ammonium salts
HMDB ID
HMDB0240646
Formula
C25H46NO2
Structure
2D MOL
Function
Dihomo-gamma-linolenoylcholine, also known as choline dihomolinolenic acid, belongs to the class of organic compounds known as acyl cholines. These are acylated derivatives of choline. Choline or 2-hydroxy-N,N,N-trimethylethanaminium is a quaternary ammonium salt with the chemical formula (CH3)3N+(CH2)2OH. Dihomo-gamma-linolenoylcholine has been identified in blood.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Oxidoreductases (EC 1)
            Formyltetrahydrofolate dehydrogenase (ALDH1L2) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Mutation of ALDH1L2
                      Induced Change Dihomo-gamma-linolenoylcholine concentration: increase (FC = 4)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Genetic disorders of keratinisation [ICD-11: EC20]
                      Details It is reported that mutation (patients) of ALDH1L2 leads to the increase of dihomo-gamma-linolenoylcholine levels compared with control group.
References
1 Deleterious mutations in ALDH1L2 suggest a novel cause for neuro-ichthyotic syndrome. NPJ Genom Med. 2019 Jul 23;4:17.

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