Details of Metabolite

General Information of MET (ID: META00749)
Name TG(15:0/15:0/21:0)
Synonyms   Click to Show/Hide Synonyms of This Metabolite
1-pentadecanoyl-2-pentadecanoyl-3-heneicosyloyl-glycerol; TAG(15:0/15:0/21:0); TAG(51:0); TG(15:0/15:0/21:0); TG(51:0); Tracylglycerol(15:0/15:0/21:0); Tracylglycerol(51:0); Triacylglycerol; Triglyceride
Source Endogenous
Structure Type   Triradylcglycerols  (Click to Show/Hide the Complete Structure Type Hierarchy)
Lipids and lipid-like molecules
Glycerolipids
Triradylcglycerols
PubChem CID
131810035
HMDB ID
HMDB0101884
Formula
C54H104O6
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=131810035"></iframe>
3D MOL is unavailable 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
FooDB ID
FDB073708
Physicochemical Properties Molecular Weight 849.4 Topological Polar Surface Area 78.9
XlogP 23.6 Complexity 889
Heavy Atom Count 60 Rotatable Bond Count 53
Hydrogen Bond Donor Count N.A. Hydrogen Bond Acceptor Count 6
Function
TG(15:0/15:0/21:0) belongs to the family of triradyglycerols, which are glycerolipids lipids containing a common glycerol backbone to which at least one fatty acyl group is esterified. Their general formula is [R1]OCC(CO[R2])O[R3]. TG(15:0/15:0/21:0) is made up of one pentadecanoyl(R1), one pentadecanoyl(R2), and one heneicosanoyl(R3).
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Transcription factor (TF)
            Hypoxia-inducible factor 1-alpha (HIF1A) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout of HIF1A
                      Induced Change TG(15:0/15:0/21:0) concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Colorectal cancer [ICD-11: 2B91]
                      Details It is reported that knockout of HIF1A leads to the increase of TG(15:0/15:0/21:0) levels compared with control group.
References
1 Hypoxia induces a lipogenic cancer cell phenotype via HIF1-dependent and -independent pathways. Oncotarget. 2015 Feb 10;6(4):1920-41.

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