Details of Metabolite

General Information of MET (ID: META00747)
Name DTDP-alpha-D-glucose(2-)
Synonyms   Click to Show/Hide Synonyms of This Metabolite
Deoxythymidine diphosphate-glucose; dTDP-Glucose dianion; dTDP-Glucose(2-); dTDP-a-D-Glucose; dTDP-alpha-D-Glucose
Source Aromatic heteromonocyclic compounds
Structure Type   Pyrimidine nucleotide sugars  (Click to Show/Hide the Complete Structure Type Hierarchy)
Nucleosides, nucleotides, and analogues
Pyrimidine nucleotides
Pyrimidine nucleotide sugars
PubChem CID
684
HMDB ID
HMDB0062805
Formula
C16H26N2O16P2
Structure
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3D MOL is unavailable 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
ChEBI ID
57477
FooDB ID
FDB030839
ChemSpider ID
664
Physicochemical Properties Molecular Weight 564.3 Topological Polar Surface Area 271
XlogP -5.5 Complexity 978
Heavy Atom Count 36 Rotatable Bond Count 9
Hydrogen Bond Donor Count 8 Hydrogen Bond Acceptor Count 16
Function
DTDP-alpha-D-glucose(2-) is also known as dTDP-a-D-Glucose or dTDP-Glucose dianion. DTDP-alpha-D-glucose(2-) is considered to be soluble (in water) and acidic. DTDP-alpha-D-glucose(2-) can be found throughout numerous foods such as Common walnuts, Sacred lotus, Ryes, and Tea. DTDP-alpha-D-glucose(2-) may be a unique E.coli metabolite
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Transcription factor (TF)
            Forkhead box protein O1 (FOXO1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Overexpression of Foxo1
                      Induced Change DTDP-alpha-D-glucose(2-) concentration: decrease (FC = 0.60)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that overexpression of Foxo1 leads to the decrease of DTDP-alpha-D-glucose(2-) levels compared with control group.
References
1 Metabolomic analysis of C2C12 myoblasts induced by the transcription factor FOXO1. FEBS Lett. 2019 Jun;593(12):1303-1312.

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