Details of Metabolite

General Information of MET (ID: META00738)
Name 2'-Deoxycytidine 3'-monophosphate
Synonyms   Click to Show/Hide Synonyms of This Metabolite
2'-Deoxycytidine 3'-monophosphoric acid, '{[5-(2-hydroxy-4-imino-1,4-dihydropyrimidin-1-yl)-2-(hydroxymethyl)oxolan-3-yl]oxy}phosphonate
Source Aromatic heteromonocyclic compounds
Structure Type   Ribonucleoside 3'-phosphates  (Click to Show/Hide the Complete Structure Type Hierarchy)
Nucleosides, nucleotides, and analogues
Ribonucleoside 3'-phosphates
PubChem CID
3274948
HMDB ID
HMDB0062545
Formula
C9H14N3O7P
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
Physicochemical Properties Molecular Weight 307.2 Topological Polar Surface Area 155
XlogP -3 Complexity 502
Heavy Atom Count 20 Rotatable Bond Count 4
Hydrogen Bond Donor Count 4 Hydrogen Bond Acceptor Count 7
Function
2'-deoxycytidine 3'-monophosphate is classified as a member of the Ribonucleoside 3'-phosphates. Ribonucleoside 3'-phosphates are ribonucleosides that contain a phosphate group attached to the C-3 carbon of the ribose or deoxyribose moiety. The nucleobases here are limited to purine, pyrimidine, and pyridine derivatives. 2'-deoxycytidine 3'-monophosphate is considered to be soluble (in water) and acidic
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Transferases (EC 2)
            Pyridoxal kinase (PDXK) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout (CRISPR/Cas9 sgRNA) of PDXK
                      Induced Change 2'-Deoxycytidine 3'-monophosphate concentration: decrease
                      Summary Introduced Variation         Induced Change 
                      Disease Status Acute myeloid leukaemia [ICD-11: 2A60]
                      Details It is reported that knockout of PDXK leads to the decrease of 2'-deoxycytidine 3'-monophosphate levels compared with control group.
References
1 Vitamin B6 Addiction in Acute Myeloid Leukemia. Cancer Cell. 2020 Jan 13;37(1):71-84.e7.

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