Details of Metabolite

General Information of MET (ID: META00737)
Name Pentadecanoylcarnitine
Synonyms   Click to Show/Hide Synonyms of This Metabolite
C15 Carnitine; Pentadecanoylcarnitine
Source Endogenous
Structure Type   Fatty acid esters  (Click to Show/Hide the Complete Structure Type Hierarchy)
Lipids and lipid-like molecules
Fatty Acyls
Fatty acid esters
PubChem CID
123132011
HMDB ID
HMDB0062517
Formula
C22H43NO4
Structure
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3D MOL is unavailable 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
ChEBI ID
131886
Physicochemical Properties Molecular Weight 385.6 Topological Polar Surface Area 66.4
XlogP 7.2 Complexity 385
Heavy Atom Count 27 Rotatable Bond Count 18
Hydrogen Bond Donor Count N.A. Hydrogen Bond Acceptor Count 4
Function
Pentadecanoylcarnitine is also known as C15 Carnitine. Pentadecanoylcarnitine is considered to be practically insoluble (in water) and acidic
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Oxidoreductases (EC 1)
            Formyltetrahydrofolate dehydrogenase (ALDH1L2) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Mutation of ALDH1L2
                      Induced Change Pentadecanoylcarnitine concentration: increase (FC = 7.69)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Genetic disorders of keratinisation [ICD-11: EC20]
                      Details It is reported that mutation (patients) of ALDH1L2 leads to the increase of pentadecanoylcarnitine levels compared with control group.
References
1 Deleterious mutations in ALDH1L2 suggest a novel cause for neuro-ichthyotic syndrome. NPJ Genom Med. 2019 Jul 23;4:17.

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