Details of Metabolite

General Information of MET (ID: META00714)
Name D-4-Hydroxy-2-oxoglutarate
Synonyms   Click to Show/Hide Synonyms of This Metabolite
(R)-2-Hydroxy-4-ketopentanedioate; (R)-2-Hydroxy-4-ketopentanedioic acid; (R)-2-Hydroxy-4-oxopentanedioate; (R)-2-Hydroxy-4-oxopentanedioic acid; D-4-Hydroxy-2-ketoglutarate; D-4-Hydroxy-2-ketoglutaric acid; D-4-Hydroxy-2-oxoglutaric acid
Source Microbial
Structure Type   Gamma-keto acids and derivatives  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic acids and derivatives
Keto acids and derivatives
Gamma-keto acids and derivatives
PubChem CID
440853
HMDB ID
HMDB0060466
Formula
C5H6O6
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C05946
ChEBI ID
4083
ChemSpider ID
389695
Physicochemical Properties Molecular Weight 162.1 Topological Polar Surface Area 112
XlogP -1.4 Complexity 195
Heavy Atom Count 11 Rotatable Bond Count 4
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 6
Function
This compound belongs to the family of Gamma Keto-Acids and Derivatives. These are organic compounds containing an aldehyde substituted with a keto group on the C4 carbon atom
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Lyases (EC 4)
            Dihydrodipicolinate synthase-like (DHDPSL) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Mutation (patients: bi-allelic mutations) of HOGA1
                      Induced Change D-4-Hydroxy-2-oxoglutarate concentration: increase (FC = 50)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Carbohydrate metabolism disorders [ICD-11: 5C51]
                      Details It is reported that mutation (patients with bi-allelic mutations) of HOGA1 leads to the increase of D-4-hydroxy-2-oxoglutarate levels compared with control group.
References
1 Primary hyperoxaluria type III--a model for studying perturbations in glyoxylate metabolism. J Mol Med (Berl). 2012 Dec;90(12):1497-504.

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