Details of Metabolite

General Information of MET (ID: META00702)
Name (S)-Ethylmalonyl-CoA
Synonyms   Click to Show/Hide Synonyms of This Metabolite
(2S)-2-Ethylmalonyl-CoA; (2S)-Ethylmalonyl coenzyme A; (S)-2-Ethylmalonyl-CoA; (S)-Ethylmalonyl coenzyme A; (S)-Ethylmalonyl-CoA; EtMal-CoA; Ethylmalonyl coenzyme A; Ethylmalonyl-CoA; Ethylmalonyl-coenzyme A
Source Endogenous;Fatty acyls
Structure Type   Fatty acyl thioesters  (Click to Show/Hide the Complete Structure Type Hierarchy)
Lipids and lipid-like molecules
Fatty Acyls
Fatty acyl thioesters
PubChem CID
49852422
HMDB ID
HMDB0059619
Formula
C26H42N7O19P3S
Structure
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3D MOL is unavailable 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C18026
ChEBI ID
60907
Physicochemical Properties Molecular Weight 881.6 Topological Polar Surface Area 426
XlogP -5 Complexity 1550
Heavy Atom Count 56 Rotatable Bond Count 23
Hydrogen Bond Donor Count 10 Hydrogen Bond Acceptor Count 24
Function
(s)-ethylmalonyl-coa is a substrate for: Ethylmalonyl-CoA decarboxylase.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Lyases (EC 4)
            Ethylmalonyl-CoA decarboxylase (ECHDC1) Click to Show/Hide the Full List of Regulating Pair(s):   2 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair (1) Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout of Echdc1
                      Induced Change (S)-Ethylmalonyl-CoA concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that knockout of Echdc1 leads to the increase of (S)-ethylmalonyl-CoA levels compared with control group.
               Regulating Pair (2) Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Overexpression of Echdc1
                      Induced Change (S)-Ethylmalonyl-CoA concentration: decrease
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that overexpression of Echdc1 leads to the decrease of (S)-ethylmalonyl-CoA levels compared with control group.
References
1 The synthesis of branched-chain fatty acids is limited by enzymatic decarboxylation of ethyl- and methylmalonyl-CoA. Biochem J. 2019 Aug 30;476(16):2427-2447.

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