Details of Metabolite

General Information of MET (ID: META00679)
Name Glycylglycylglycine
Synonyms   Click to Show/Hide Synonyms of This Metabolite
(([(Aminoacetyl)amino]acetyl)amino)acetic acid; (Gly)3; Diglycyl-glycine; Diglycylglycine; GGG; GGG Peptide; GLYCYL-glycyl-glycine; Gly-gly-gly; GlyGlyGly; Glycine, N-(N-glycylglycyl)- (8ci)(9ci); Glycylpeptide; N-(N-GLYCYLGLYCYL)-glycine; N-(N-Glycylglycyl)glycine; Triglycine; Triglycine sulfate
Source Endogenous;Food
Structure Type   Amino acids, peptides, and analogues  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic acids and derivatives
Carboxylic acids and derivatives
Amino acids, peptides, and analogues
PubChem CID
11161
HMDB ID
HMDB0029419
Formula
C6H11N3O4
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=11161"></iframe>
3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
ChEBI ID
63961
FooDB ID
FDB000517
ChemSpider ID
10688
Physicochemical Properties Molecular Weight 189.17 Topological Polar Surface Area 122
XlogP -3.6 Complexity 216
Heavy Atom Count 13 Rotatable Bond Count 5
Hydrogen Bond Donor Count 4 Hydrogen Bond Acceptor Count 5
Function
Glycylglycylglycine is found in fruits. Glycylglycylglycine is isolated from the seeds of Blighia sapida (akee apple
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Proton-dependent oligopeptide transporter (POT/PTR)
            Solute carrier family 15 member 4 (SLC15A4) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Mutation (L14A, L15A, L318A, V319A) of SLC15A4
                      Induced Change Glycylglycylglycine concentration: increase (FC = 2 - 4)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that mutation (L14A and L15A or L318A and V319A) of SLC15A4 leads to the increase of glycylglycylglycine levels compared with control group.
References
1 Functional Characterization of Human Peptide/Histidine Transporter 1 in Stably Transfected MDCK Cells. Mol Pharm. 2018 Feb 5;15(2):385-393.

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