Details of Metabolite

General Information of MET (ID: META00678)
Name L-Targinine
Synonyms   Click to Show/Hide Synonyms of This Metabolite
Acide (2S)-2-amino-5-(3-methylguanidino)pentanoique; Arginine, L-NG-monomethyl; D-NMMA; L Monomethylarginine; L NG Monomethyl arginine; L-Monomethylarginine; L-NG-Monomethyl arginine; L-NMMA; N(5)-(Methylamidino)-L-ornithine; N(5)-(Metilamidino)-L-ornitina; N(5)-(N-Methylcarbamimidoyl)-L-ornithine; N(5)-[Imino(methylamino)methyl]-L-ornithine; N(Omega)-methyl-L-arginine; N(Omega)-monomethyl-L-arginine; N(g)-Methylarginine; N(g)-Monomethyl-D-arginine; N(g)-Monomethyl-L-arginine; N(g)-Monomethylarginine; N-Methyl-L-arginine; N-Monomethyl-L-arginine; N-Omega-methyl-L-arginine; N-Omega-monomethyl-L-arginine; N5-(N-Methylcarbamimidoyl)-L-ornithine; NG Monomethyl L arginine; NG-Monomethyl-L-argine; NG-Monomethyl-L-arginine; Ngamma-monomethyl-L-arginine; Omega N methylarginine; Omega-N-methylarginine; Omega-N-monomethylarginine; Targinina; Targinine; Targininum; Tilarginina; Tilarginine; Tilargininum
Source Endogenous;Food
Structure Type   Amino acids, peptides, and analogues  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic acids and derivatives
Carboxylic acids and derivatives
Amino acids, peptides, and analogues
PubChem CID
132862
HMDB ID
HMDB0029416
Formula
C7H16N4O2
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C03884
DrugBank ID
DB11815
ChEBI ID
28229
FooDB ID
FDB000510
ChemSpider ID
117259
Physicochemical Properties Molecular Weight 188.23 Topological Polar Surface Area 114
XlogP -4.1 Complexity 193
Heavy Atom Count 13 Rotatable Bond Count 6
Hydrogen Bond Donor Count 4 Hydrogen Bond Acceptor Count 4
Function
L-Targinine is found in pulses. L-Targinine is isolated from broad bean seed L-Targinine has been identified in the human placenta.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      GPCR secretin (GPCR-2)
            Glucagon receptor (GCGR) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout of Gcgr
                      Induced Change L-Targinine concentration: increase (FC = 4.3)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Type 2 diabetes mellitus [ICD-11: 5A11]
                      Details It is reported that knockout of GCGR leads to the increase of L-targinine levels compared with control group.
      Pore-forming PNC peptide (PNC)
            Cellular tumor antigen p53 (TP53) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [2]
                      Introduced Variation Knockout of TP53
                      Induced Change L-Targinine concentration: increase (Log2 FC=1.32)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Colon cancer [ICD-11: 2B90]
                      Details It is reported that knockout of TP53 leads to the increase of L-targinine levels compared with control group.
References
1 Polyomic profiling reveals significant hepatic metabolic alterations in glucagon-receptor (GCGR) knockout mice: implications on anti-glucagon therapies for diabetes. BMC Genomics. 2011 Jun 1;12:281.
2 Integrative omics analysis of p53-dependent regulation of metabolism. FEBS Lett. 2018 Feb;592(3):380-393.

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