Details of Metabolite

General Information of MET (ID: META00656)
Name Phenelzine
Synonyms   Click to Show/Hide Synonyms of This Metabolite
2 Phenethylhydrazine; 2-Phenethylhydrazine; Fenelzin; Nardelzine; Nardil; Parke davis brand OF phenelzine sulfate; Pfizer brand OF phenelzine sulfate; Phenelzine sulfate; Phenethylhydrazine; Sulfate, phenelzine; United drug brand OF phenelzine sulfate; Warner chilcott brand OF phenelzine sulfate; beta Phenylethylhydrazine; beta-Phenylethylhydrazine
Source Drug;Toxins/Pollutant
Structure Type   Benzene and substituted derivatives  (Click to Show/Hide the Complete Structure Type Hierarchy)
Benzenoids
Benzene and substituted derivatives
PubChem CID
3675
HMDB ID
HMDB0014918
Formula
C8H12N2
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C07430
DrugBank ID
DB00780
ChEBI ID
248018
ChemSpider ID
3547
Physicochemical Properties Molecular Weight 136.19 Topological Polar Surface Area 38
XlogP 1.2 Complexity 77.3
Heavy Atom Count 10 Rotatable Bond Count 3
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 2
Function
Phenelzine is only found in individuals that have used or taken this drug. It is an irreversible non-selective inhibitor of monoamine oxidase. May be used to treat major depressive disorder.Although the exact mechanism of action has not been determined, it appears that the irreversible, nonselective inhibition of MAO by phenelzine relieves depressive symptoms by causing an increase in the levels of serotonin, norepinephrine, and dopamine in the neuron.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Amino acid/polyamine transporter (AAPT)
            Integral membrane E16 (SLC7A5) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Overexperisson of SLC7A5
                      Induced Change Phenelzine concentration: decrease
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that co-overexperisson of SLC7A5 and SLC7A8 leads to the decrease of phenelzine levels compared with control group.
            L-type amino acid transporter 2 (LAT2) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Overexperisson of SLC7A8
                      Induced Change Phenelzine concentration: decrease
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that co-overexperisson of SLC7A5 and SLC7A8 leads to the decrease of phenelzine levels compared with control group.
References
1 Identification of a membrane protein, LAT-2, that Co-expresses with 4F2 heavy chain, an L-type amino acid transport activity with broad specificity for small and large zwitterionic amino acids. J Biol Chem. 1999 Jul 9;274(28):19738-44.

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