Details of Metabolite

General Information of MET (ID: META00641)
Name Beta-Guanidinopropionic acid
Synonyms   Click to Show/Hide Synonyms of This Metabolite
3-Guanidinopropanoate; 3-Guanidinopropanoic acid; 3-Guanidinopropionic acid; Amidino beta-alanine; Guanidine propionate; Guanidinopropionate; Guanidinopropionic acid; N-[Amino(imino)methyl]-beta-alanine; b-Guanidinopropionate; b-Guanidinopropionic acid; beta-GPA; beta-Guanadinopropionate; beta-Guanidine propionic acid; beta-Guanidinopropionic acid; beta-Guanidinopropionic acid.
Source Endogenous;Food
Structure Type   Guanidines  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic nitrogen compounds
Organonitrogen compounds
Guanidines
PubChem CID
67701
HMDB ID
HMDB0013222
Formula
C4H9N3O2
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C03065
ChEBI ID
15968
FooDB ID
FDB029341
ChemSpider ID
61020
Physicochemical Properties Molecular Weight 131.13 Topological Polar Surface Area 102
XlogP -1.8 Complexity 128
Heavy Atom Count 9 Rotatable Bond Count 3
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 3
Function
Beta-Guanidinopropionic acid is analog of creatine and is reported to decrease phosphocreatine and ATP content in animal tissues in vivo.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Transcription factor (TF)
            Forkhead box protein O1 (FOXO1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Overexpression of Foxo1
                      Induced Change Beta-Guanidinopropionic acid concentration: decrease (FC = 0.80)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that overexpression of Foxo1 leads to the decrease of beta-Guanidinopropionic acid levels compared with control group.
      Transferases (EC 2)
            Arylamine N-acetyltransferase 1 (NAT1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [2]
                      Introduced Variation Knockout of NAT1
                      Induced Change Beta-Guanidinopropionic acid concentration: decrease (FC = 0.3)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Breast cancer [ICD-11: 2C60]
                      Details It is reported that knockout of NAT1 leads to the decrease of beta-Guanidinopropionic acid levels compared with control group.
References
1 Metabolomic analysis of C2C12 myoblasts induced by the transcription factor FOXO1. FEBS Lett. 2019 Jun;593(12):1303-1312.
2 CRISPR/Cas9 knockout of human arylamine N-acetyltransferase 1 in MDA-MB-231 breast cancer cells suggests a role in cellular metabolism. Sci Rep. 2020 Jun 17;10(1):9804.

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