Details of Metabolite

General Information of MET (ID: META00637)
Name 9-Hexadecenoylcarnitine
Synonyms   Click to Show/Hide Synonyms of This Metabolite
(3R)-3-[(9Z)-Hexadec-9-enoyloxy]-4-(trimethylazaniumyl)butanoic acid; 9-Hexadecenoylcarnitine; Palmitoleoylcarnitine
Source Endogenous;Food
Structure Type   Fatty acid esters  (Click to Show/Hide the Complete Structure Type Hierarchy)
Lipids and lipid-like molecules
Fatty Acyls
Fatty acid esters
HMDB ID
HMDB0013207
Formula
C23H43NO4
Structure
2D MOL
ChemSpider ID
28639183
Function
9-Hexadecenoylcarnitine, also known as palmitoleoylcarnitine, is considered to be a practically insoluble (in water) and a weak acidic compound. 9-hexadecenoylcarnitine can be found in blood. Within a cell, 9-hexadecenoylcarnitine is primarily located in the extracellular space and near the membrane. This compound belongs to the class of chemical entities known as fatty acid esters. These are carboxylic ester derivatives of a fatty acid. 9-Hexadecenoylcarnitine is found to be associated with glutaric aciduria II, which is an inborn error of metabolism.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Oxidoreductases (EC 1)
            Formyltetrahydrofolate dehydrogenase (ALDH1L2) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Mutation of ALDH1L2
                      Induced Change 9-Hexadecenoylcarnitine concentration: increase (FC = 7.69)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Genetic disorders of keratinisation [ICD-11: EC20]
                      Details It is reported that mutation (patients) of ALDH1L2 leads to the increase of 9-hexadecenoylcarnitine levels compared with control group.
References
1 Deleterious mutations in ALDH1L2 suggest a novel cause for neuro-ichthyotic syndrome. NPJ Genom Med. 2019 Jul 23;4:17.

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