Details of Metabolite

General Information of MET (ID: META00560)
Name N-Acetylasparagine
Synonyms   Click to Show/Hide Synonyms of This Metabolite
(2S)-3-(C-Hydroxycarbonimidoyl)-2-[(1-hydroxyethylidene)amino]propanoate; AcAsn; N-Acetyl-L-asparagine; N-Acetylasparagine; N-Acetylasparagine, (14)C-labeled; N-Acetylasparagine, (D)-isomer; N-Acetylasparagine, (D,L)-isomer; N2-Acetyl-L-asparagine
Source Endogenous;Food
Structure Type   Amino acids, peptides, and analogues  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic acids and derivatives
Carboxylic acids and derivatives
Amino acids, peptides, and analogues
PubChem CID
99715
HMDB ID
HMDB0006028
Formula
C6H10N2O4
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
FooDB ID
FDB023807
ChemSpider ID
90090
Physicochemical Properties Molecular Weight 174.15 Topological Polar Surface Area 110
XlogP -1.8 Complexity 214
Heavy Atom Count 12 Rotatable Bond Count 4
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 4
Function
N-Acetylasparagine is produced by degradation of asparagine and identified in human urine.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Transferases (EC 2)
            Arylamine N-acetyltransferase 1 (NAT1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout of NAT1
                      Induced Change N-Acetylasparagine concentration: decrease (FC = 0.1)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Breast cancer [ICD-11: 2C60]
                      Details It is reported that knockout of NAT1 leads to the decrease of N-acetylasparagine levels compared with control group.
References
1 CRISPR/Cas9 knockout of human arylamine N-acetyltransferase 1 in MDA-MB-231 breast cancer cells suggests a role in cellular metabolism. Sci Rep. 2020 Jun 17;10(1):9804.

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