Details of Metabolite

General Information of MET (ID: META00557)
Name Sorbitol-6-phosphate
Synonyms   Click to Show/Hide Synonyms of This Metabolite
Alditol 6-phosphate; D-Mannitol, 1-(dihydrogenphosphate); D-Mannitol-6-phosphate; D-Sorbitol 6-phosphate; Glucitol-6-phosphate; Hexitol 1-phosphate; Hexitol 1-phosphoric acid; Sorbitol 6-phosphate; Sorbitol-6-phosphoric acid
Source Endogenous;Escherichia Coli Metabolite;Food
Structure Type   Carbohydrates and carbohydrate conjugates  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic oxygen compounds
Organooxygen compounds
Carbohydrates and carbohydrate conjugates
PubChem CID
618
HMDB ID
HMDB0005831
Formula
C6H15O9P
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C02810
ChEBI ID
743019
FooDB ID
FDB023777
ChemSpider ID
598
Physicochemical Properties Molecular Weight 262.15 Topological Polar Surface Area 168
XlogP -4.7 Complexity 240
Heavy Atom Count 16 Rotatable Bond Count 7
Hydrogen Bond Donor Count 7 Hydrogen Bond Acceptor Count 9
Function
Sorbitol 6-phosphate (Sor6P) is an intermediate in sorbitol biosynthesis. It is a competitive inhibitor for both cytosolic and chloroplastic PGIs with a K(i) of 61 and 40muM, respectively. PMID: 18242768.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Transcription factor (TF)
            Forkhead box protein O1 (FOXO1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Overexpression of Foxo1
                      Induced Change Sorbitol-6-phosphate concentration: increase (FC = 1.40)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that overexpression of Foxo1 leads to the increase of sorbitol-6-phosphate levels compared with control group.
References
1 Metabolomic analysis of C2C12 myoblasts induced by the transcription factor FOXO1. FEBS Lett. 2019 Jun;593(12):1303-1312.

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